{"id":"W3177969697","doi":"10.1093/jnci/djab118","title":"Li-Fraumeni Syndrome in the Cancer Genomics Era","year":2021,"lang":"en","type":"letter","venue":"JNCI Journal of the National Cancer Institute","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Li–Fraumeni syndrome; Cancer; Genomics; Medicine; Genetics; Biology; Computational biology; Bioinformatics; Oncology; Genome; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001340359,0.0005046771,0.00107017,0.0007113137,0.002809174,0.002041233,0.0009105678,0.02278621,0.004574574],"category_scores_gemma":[0.008922501,0.0003555417,0.0006300864,0.0005589934,0.002008883,0.002174015,0.00094597,0.01863924,0.001661895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003175559,"about_ca_system_score_gemma":0.002798077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005117724,"about_ca_topic_score_gemma":0.007634699,"domain_scores_codex":[0.9989261,0.000346522,0.00009633365,0.0001596941,0.0002897874,0.0001814353],"domain_scores_gemma":[0.9968858,0.00171695,0.0001512838,0.0001069314,0.0003975764,0.0007413098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001358093,0.00009820706,0.006414711,0.00009696594,0.00004545933,0.04114155,0.0002738985,0.0003247571,0.0008611923,0.01238977,0.9115175,0.02670008],"study_design_scores_gemma":[0.000402738,0.0002013563,0.007914297,0.0008206455,0.0001414397,0.08763448,0.001219014,0.002508602,0.0008110638,0.05034341,0.8478937,0.0001092947],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001535886,0.002646463,0.0001058308,0.98061,0.01028771,0.000006239282,0.00003365584,0.00002146702,0.004752709],"genre_scores_gemma":[0.03390862,0.006929916,0.0006470656,0.845619,0.1031081,0.00003531948,0.00006454182,0.0000440704,0.009643428],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02278621,"threshold_uncertainty_score":0.02304035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05584663260092314,"score_gpt":0.3189954067304891,"score_spread":0.2631487741295659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}