{"id":"W3177969697","doi":"10.1093/jnci/djab118","title":"Li-Fraumeni Syndrome in the Cancer Genomics Era","year":2021,"lang":"en","type":"letter","venue":"JNCI Journal of the National Cancer Institute","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Li–Fraumeni syndrome; Cancer; Genomics; Medicine; Genetics; Biology; Computational biology; Bioinformatics; Oncology; Genome; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0007629883,0.0003676214,0.0007008225,0.0003803038,0.000153361,0.00009012426,0.001040341,0.0006141115,0.0002912253],"category_scores_gemma":[0.0003285202,0.0002285429,0.0006531638,0.0007691791,0.000198479,0.0001937852,0.0001314567,0.005543029,0.000009772439],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.004132433,"about_ca_system_score_gemma":0.008851625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003888627,"about_ca_topic_score_gemma":0.0006047381,"domain_scores_codex":[0.9956946,0.0001842249,0.000962509,0.0003360942,0.00244484,0.0003777072],"domain_scores_gemma":[0.9972373,0.0001176646,0.001033967,0.000408973,0.00112638,0.00007570511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001113924,0.00006824352,0.0001809162,0.0001944634,0.0007621974,0.002967564,0.00033122,0.00762262,0.0009903896,0.00008258142,0.9855646,0.001123792],"study_design_scores_gemma":[0.001707732,0.00007180848,0.003653153,0.001676635,0.0005221967,0.007083741,0.00001826917,0.00006085346,0.0004095304,0.0003257664,0.9842218,0.0002485346],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.02654974,0.01535599,0.00005835544,0.9423442,0.0124709,0.0006816054,0.0003867664,0.00001093469,0.002141488],"genre_scores_gemma":[0.03383678,0.004822346,0.0004220247,0.9377521,0.02018847,0.000150896,0.0001045143,0.0001118542,0.002611071],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01053364,"threshold_uncertainty_score":0.9996905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05584663260092314,"score_gpt":0.3189954067304891,"score_spread":0.2631487741295659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}