{"id":"W3178030326","doi":"10.1158/1538-7445.am2021-886","title":"Abstract 886: Prediction of outcome in Li-Fraumeni Syndrome: Development of an integrative function-based prognostic model","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Penetrance; Germline; Germline mutation; Medicine; Oncology; Internal medicine; Cohort; Li–Fraumeni syndrome; Cancer; Genetics; Mutation; Biology; Phenotype; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00332165,0.001712208,0.001638645,0.002198548,0.0004305977,0.001551983,0.001447436,0.001005307,0.002733368],"category_scores_gemma":[0.004680809,0.0002564193,0.00135367,0.0009238533,0.0004196093,0.0005471827,0.001004345,0.00145067,0.0009816492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008122783,"about_ca_system_score_gemma":0.001228406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009949468,"about_ca_topic_score_gemma":0.003424434,"domain_scores_codex":[0.9993172,0.0002644324,0.00004395739,0.0001868452,0.00009508751,0.00009254042],"domain_scores_gemma":[0.9977589,0.001335477,0.0001944676,0.00009871402,0.0003834822,0.0002289248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001553122,0.0008087661,0.2592028,0.0001119779,0.000919777,0.0003606227,0.0001050394,0.6220961,0.001416361,0.001537373,0.01162244,0.1002656],"study_design_scores_gemma":[0.00002584872,0.00009983421,0.005246401,0.00001400121,0.00006507218,0.00003304355,0.00001462366,0.9931138,0.0001219297,0.0010838,0.0001711808,0.00001034774],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7423581,0.00210181,0.2370473,0.003696177,0.0002615085,0.0003155673,0.008984528,0.001932258,0.003302701],"genre_scores_gemma":[0.9773133,0.0002906412,0.0150008,0.0001739029,0.0001266089,0.0001702318,0.005704642,0.00004798735,0.001171808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009949468,"threshold_uncertainty_score":0.01978314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1012172210200378,"score_gpt":0.3943861726274386,"score_spread":0.2931689516074008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}