{"id":"W3178036525","doi":"10.1371/journal.ppat.1009705","title":"SARS-CoV-2 infection in the Syrian hamster model causes inflammation as well as type I interferon dysregulation in both respiratory and non-respiratory tissues including the heart and kidney","year":2021,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University; University of Manitoba; University of Saskatchewan","funders":"Canada Foundation for Innovation; Research Nova Scotia; Nova Scotia Health Research Foundation; Canadian Institutes of Health Research; Innovation Saskatchewan; Genome Canada","keywords":"Myocarditis; Inflammation; Medicine; Respiratory system; Kidney; Immunology; Interferon; Respiratory tract; Hamster; Coronavirus; Respiratory disease; Lung; Disease; Pathology; Coronavirus disease 2019 (COVID-19); Internal medicine; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002539307,0.0004373121,0.0003775729,0.000443191,0.0002733662,0.0002521867,0.000138457,0.000363195,0.00167484],"category_scores_gemma":[0.00008755775,0.0001763879,0.0003768659,0.000203986,0.0003688571,0.0002749617,0.0002575451,0.0005773979,0.0002826694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002367971,"about_ca_system_score_gemma":0.0002430298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006154648,"about_ca_topic_score_gemma":0.001456541,"domain_scores_codex":[0.9998444,0.00002982313,0.00001970681,0.00004172504,0.0000268145,0.00003752124],"domain_scores_gemma":[0.9998727,0.00001301789,0.00003746905,0.00002098915,0.00001221046,0.00004371161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001044471,0.000286129,0.003262238,0.00009253511,0.00001980017,0.0003236808,0.00007482767,0.00006653375,0.9933423,0.0001204953,0.0001021087,0.001264915],"study_design_scores_gemma":[0.0002453646,0.01940155,0.1354535,0.00005366179,0.0001433569,0.002119227,0.0005607713,0.0011532,0.8352223,0.0003104643,0.00530465,0.000031966],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970149,0.0008642608,0.0003464686,0.00006107196,0.00005128532,0.00004629894,0.0004503067,0.00002328694,0.001142086],"genre_scores_gemma":[0.993288,0.001149305,0.001077812,0.0001022364,0.00002373813,0.00009278092,0.0007421658,0.000006842622,0.003517264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00167484,"threshold_uncertainty_score":0.005602896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1173652595955576,"score_gpt":0.4104324162706785,"score_spread":0.2930671566751208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}