{"id":"W3178128501","doi":"10.1158/1538-7445.am2021-ct003","title":"Abstract CT003: Nivolumab (NIVO) + platinum-doublet chemotherapy (chemo) vs chemo as neoadjuvant treatment (tx) for resectable (IB-IIIA) non-small cell lung cancer (NSCLC) in the phase 3 CheckMate 816 trial","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Medicine; Oncology; Internal medicine; Nivolumab; Lung cancer; Clinical endpoint; non-small cell lung cancer (NSCLC); Neoadjuvant therapy; Chemotherapy; Clinical trial; Cancer; Immunotherapy; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002110049,0.0005321576,0.0009244921,0.0003058574,0.0004595397,0.0002567969,0.0005933995,0.0003507082,0.003801899],"category_scores_gemma":[0.0001077123,0.0003961895,0.0004756237,0.001277445,0.0002714132,0.0001753105,0.00008646454,0.0008951466,0.00003072837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002741146,"about_ca_system_score_gemma":0.005176924,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01391689,"about_ca_topic_score_gemma":0.003120711,"domain_scores_codex":[0.9950836,0.0002166837,0.000823339,0.001120584,0.001163787,0.001592041],"domain_scores_gemma":[0.9971753,0.0005182073,0.0002172009,0.001177862,0.0006318663,0.0002796116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.3309132,0.003338118,0.0009196537,0.001054216,0.0007692404,0.0004353131,0.006155229,0.00003016483,0.5315332,0.00001828372,0.03959496,0.08523844],"study_design_scores_gemma":[0.2680447,0.002987163,0.001260756,0.00096212,0.0001278913,0.0000333665,0.001479394,0.0004193219,0.6090018,0.00005217137,0.1151159,0.0005154278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9648442,0.01397953,0.00002165065,0.007396125,0.0006161809,0.006172106,0.0002347538,0.00005341793,0.006682086],"genre_scores_gemma":[0.9481524,0.01786065,0.0002049207,0.001741238,0.002144495,0.007249766,0.0002417359,0.0002049441,0.02219982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08472301,"threshold_uncertainty_score":0.999849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0873477316640326,"score_gpt":0.4349127324397565,"score_spread":0.3475650007757239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}