{"id":"W3178128501","doi":"10.1158/1538-7445.am2021-ct003","title":"Abstract CT003: Nivolumab (NIVO) + platinum-doublet chemotherapy (chemo) vs chemo as neoadjuvant treatment (tx) for resectable (IB-IIIA) non-small cell lung cancer (NSCLC) in the phase 3 CheckMate 816 trial","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Medicine; Oncology; Internal medicine; Nivolumab; Lung cancer; Clinical endpoint; non-small cell lung cancer (NSCLC); Neoadjuvant therapy; Chemotherapy; Clinical trial; Cancer; Immunotherapy; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001534698,0.001025546,0.001330812,0.0002057736,0.0002751248,0.0008677635,0.000734751,0.001106717,0.007295249],"category_scores_gemma":[0.001127449,0.0002521783,0.001814421,0.0003090155,0.0006470146,0.0005407208,0.0003339725,0.002262584,0.0007308404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000854987,"about_ca_system_score_gemma":0.001196752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001151162,"about_ca_topic_score_gemma":0.004205527,"domain_scores_codex":[0.9995716,0.0002797692,0.00001959648,0.00005557195,0.00002459041,0.00004891172],"domain_scores_gemma":[0.9992157,0.0002375359,0.0001513789,0.00004020628,0.00003947158,0.0003157505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9804744,0.002959375,0.001076788,0.0004057857,0.0006653907,0.00003268682,0.00002493229,0.0004622287,0.00387713,0.000113161,0.002087126,0.007821035],"study_design_scores_gemma":[0.893347,0.09706805,0.004499635,0.00005913346,0.001281168,0.00005737455,0.00002768544,0.0009376116,0.001010804,0.0003604154,0.001332938,0.00001821441],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810303,0.003641941,0.0006434983,0.001226558,0.0005288892,0.003467349,0.004994389,0.0001522054,0.004314851],"genre_scores_gemma":[0.9842859,0.001183247,0.001154428,0.001503325,0.0003248674,0.003321671,0.003675868,0.00003178311,0.004519003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007295249,"threshold_uncertainty_score":0.02440506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0873477316640326,"score_gpt":0.4349127324397565,"score_spread":0.3475650007757239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}