{"id":"W3178154641","doi":"10.1172/jci.insight.148652","title":"CD40L modulates transcriptional signatures of neutrophils in the bone marrow associated with development and trafficking","year":2021,"lang":"en","type":"article","venue":"JCI Insight","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"Natural Sciences and Engineering Research Council of Canada; Jeffrey Modell Foundation; United Arab Emirates University; Fundação de Amparo à Pesquisa do Estado de São Paulo; Albert-Ludwigs-Universität Freiburg; Universidade de São Paulo","keywords":"Granulopoiesis; Cell biology; Haematopoiesis; CD40; Transcriptome; Bone marrow; Biology; Transcription factor; Immunology; Stem cell; Gene expression; Gene; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001806279,0.0001592017,0.0002698446,0.00009189454,0.0001232938,0.00001516526,0.000104528,0.0001524554,0.0001030006],"category_scores_gemma":[0.00002493864,0.0001025185,0.00003878615,0.0002380365,0.0001171226,0.00007727973,0.00002390147,0.0002849005,0.000005768683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002413876,"about_ca_system_score_gemma":0.00008819205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006837604,"about_ca_topic_score_gemma":0.0001511173,"domain_scores_codex":[0.9989667,0.0002459934,0.0002541017,0.0002471195,0.00006720235,0.0002188998],"domain_scores_gemma":[0.9995553,0.0001383573,0.00008307519,0.0001267707,0.00008400452,0.00001246142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008856032,0.0002531635,0.0003000511,0.00001504552,0.0001397513,0.0001250217,0.003693303,0.0000487545,0.986778,0.007233143,0.00007386263,0.001251343],"study_design_scores_gemma":[0.001885775,0.0001810119,0.06320077,0.0001501525,0.00004191184,0.00008371802,0.0007055398,0.000005560024,0.9247441,0.000334432,0.008446436,0.0002206171],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939281,0.004855863,0.00005653779,0.0004791016,0.0001038716,0.0001469537,0.00001307751,0.00001770494,0.0003987689],"genre_scores_gemma":[0.9988913,0.00005435494,0.0001971564,0.000389179,0.00001170349,0.00001926979,0.0001330655,0.0000119496,0.0002920181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06290072,"threshold_uncertainty_score":0.4180582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0167574634106859,"score_gpt":0.2088187517029856,"score_spread":0.1920612882922997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}