{"id":"W3178154641","doi":"10.1172/jci.insight.148652","title":"CD40L modulates transcriptional signatures of neutrophils in the bone marrow associated with development and trafficking","year":2021,"lang":"en","type":"article","venue":"JCI Insight","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"Natural Sciences and Engineering Research Council of Canada; Jeffrey Modell Foundation; United Arab Emirates University; Fundação de Amparo à Pesquisa do Estado de São Paulo; Albert-Ludwigs-Universität Freiburg; Universidade de São Paulo","keywords":"Granulopoiesis; Cell biology; Haematopoiesis; CD40; Transcriptome; Bone marrow; Biology; Transcription factor; Immunology; Stem cell; Gene expression; Gene; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001337865,0.0001440045,0.0001653064,0.0002384419,0.00009424335,0.0002614841,0.00006196304,0.0001406411,0.0008789929],"category_scores_gemma":[0.000107796,0.00008581207,0.00008908025,0.0001414688,0.0001649547,0.0001226456,0.000145265,0.0002710649,0.0001730854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002006955,"about_ca_system_score_gemma":0.0001802662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003179844,"about_ca_topic_score_gemma":0.0005842906,"domain_scores_codex":[0.9998673,0.00002174304,0.000006806505,0.00003008629,0.00003134966,0.00004269156],"domain_scores_gemma":[0.9999214,0.000009041288,0.00002873759,0.000004984472,0.00001010198,0.00002565914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001040715,0.00001141317,0.0005619757,0.00001229409,0.000001178222,0.00001796558,0.00001600854,0.00001762811,0.998316,0.00004047224,0.00001703343,0.0008839053],"study_design_scores_gemma":[0.00002967517,0.0004442728,0.124834,0.00001780754,0.00002640606,0.0002273605,0.0002361683,0.001089471,0.8701715,0.0002116468,0.002701435,0.00001019009],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970658,0.001204641,0.000609813,0.00005977019,0.000009669271,0.000009993708,0.0003439002,0.0000230299,0.0006732893],"genre_scores_gemma":[0.9966559,0.0006762764,0.0005743163,0.00005736585,0.00001011514,0.00001960631,0.0004295871,0.000008929274,0.001567794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008789929,"threshold_uncertainty_score":0.002940536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0167574634106859,"score_gpt":0.2088187517029856,"score_spread":0.1920612882922997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}