{"id":"W3178189790","doi":"10.1158/1538-7445.am2021-ct219","title":"Abstract CT219: Master protocol to assess the safety and recommended Phase 2 dose of next generation NY-ESO-1-specific TCR T-cells in HLA-A*02 patients with synovial sarcoma and non-small cell lung cancer","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Medicine; Tolerability; T-cell receptor; Oncology; CD8; Internal medicine; T cell; Immunology; Tumor microenvironment; Cancer; Adverse effect; Antigen; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007651173,0.001653746,0.002144759,0.0006388333,0.001200765,0.001534919,0.002585954,0.003623809,0.03249354],"category_scores_gemma":[0.006345488,0.0009364818,0.002699798,0.0009784522,0.0007602434,0.00118678,0.0009871522,0.004443572,0.008505498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004058736,"about_ca_system_score_gemma":0.005900204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002165927,"about_ca_topic_score_gemma":0.006499717,"domain_scores_codex":[0.9955781,0.002972937,0.0003225771,0.0003366555,0.0004170888,0.000372692],"domain_scores_gemma":[0.9937043,0.0008832221,0.001713065,0.001029008,0.001095232,0.001575226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6477672,0.01984253,0.008419264,0.00394255,0.002347195,0.0004525217,0.0003387186,0.005883644,0.04669724,0.003010595,0.1386412,0.1226573],"study_design_scores_gemma":[0.3841399,0.2985802,0.04464101,0.001478517,0.001615828,0.0007110859,0.0002253765,0.003438157,0.01609308,0.003175951,0.245769,0.0001318624],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.2348505,0.006126694,0.01645615,0.006028707,0.001297538,0.5540907,0.1061744,0.001751984,0.07322336],"genre_scores_gemma":[0.2455728,0.002861925,0.02259986,0.00951546,0.0006795608,0.6141666,0.07656522,0.0005450739,0.02749344],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.03249354,"threshold_uncertainty_score":0.1087017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1512024054731531,"score_gpt":0.4203069724784636,"score_spread":0.2691045670053105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}