{"id":"W3178210198","doi":"10.1101/2021.07.09.451812","title":"Impact of temperature on the affinity of SARS-CoV-2 Spike for ACE2","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ste. Anne's Hospital; McGill University; Université de Montréal; Université Laval; Centre hospitalier de l'Université Laval; Institut National de Santé Publique du Québec; Centre hospitalier universitaire de Québec","funders":"U.S. Military HIV Research Program; Fonds de Recherche du Québec - Santé; Génome Québec; Canadian Institutes of Health Research; Ministère de la Santé; Mitacs; Ministère de la Santé et des Services sociaux; Genome Canada; Fondation du CHUM; National Science Foundation","keywords":"Spike (software development); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Receptor; Glycoprotein; Coronavirus disease 2019 (COVID-19); Viral entry; Dissociation (chemistry); Biophysics; 2019-20 coronavirus outbreak; Virology; Angiotensin-converting enzyme 2; Chemistry; Biology; Cell biology; Outbreak; Virus; Biochemistry; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002500637,0.0002309222,0.000283764,0.00009235302,0.0001510219,0.0004926088,0.0002358217,0.0002171053,0.004358174],"category_scores_gemma":[0.0005795665,0.000139809,0.0002622058,0.0001002353,0.0001686405,0.0002497504,0.0001943893,0.0004022321,0.001127088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002453805,"about_ca_system_score_gemma":0.0001907722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001939852,"about_ca_topic_score_gemma":0.001252485,"domain_scores_codex":[0.9997677,0.00005222622,0.0000135604,0.00004630107,0.00004695075,0.00007317232],"domain_scores_gemma":[0.9997595,0.00009491482,0.0000311996,0.000027482,0.0000448585,0.00004204151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001666351,0.0001331845,0.003679533,0.0000710653,0.00003114477,0.00008210555,0.0000448462,0.0008991961,0.9902878,0.0001497449,0.0004413789,0.002513633],"study_design_scores_gemma":[0.00003664476,0.0006984079,0.04093435,0.00001390481,0.00003631343,0.0002171836,0.0001270127,0.006539309,0.948682,0.000156408,0.002531544,0.00002697466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967597,0.0006074613,0.0005360107,0.0001250738,0.00005272156,0.000006215101,0.0004501953,0.000022854,0.00143961],"genre_scores_gemma":[0.997837,0.0002136636,0.000338667,0.00006076888,0.000008181874,0.000004378665,0.0004387462,0.00002687009,0.001071607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004358174,"threshold_uncertainty_score":0.01457953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05239951038824442,"score_gpt":0.3342146564448998,"score_spread":0.2818151460566554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}