{"id":"W3178248205","doi":"10.1002/eji.202149275","title":"Abortive HIV‐1 RNA induces pro‐IL‐1β maturation via protein kinase PKR and inflammasome activation in humans","year":2021,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Protein kinase R; Inflammasome; Biology; Immune system; Kinase; Proinflammatory cytokine; p38 mitogen-activated protein kinases; Cell biology; Protein kinase A; EIF-2 kinase; RNA; Interferon; Virology; Immunology; Mitogen-activated protein kinase kinase; Inflammation; Cyclin-dependent kinase 2; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002748666,0.0002518645,0.0002353289,0.0001809806,0.0001567215,0.0004532944,0.0001189874,0.0003450493,0.001644742],"category_scores_gemma":[0.000289456,0.0001622069,0.0002191458,0.00009031035,0.0003244569,0.0002571905,0.0001788498,0.0007964555,0.0004151589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002006434,"about_ca_system_score_gemma":0.0001347397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001451666,"about_ca_topic_score_gemma":0.0000874597,"domain_scores_codex":[0.9998574,0.00004138706,0.00001202573,0.00004341424,0.00002350014,0.00002223693],"domain_scores_gemma":[0.9999292,0.00001165794,0.00002829096,0.00001111346,0.000005790057,0.00001397618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00219447,0.0003027954,0.008234013,0.0002922789,0.00006898944,0.002407199,0.0002652901,0.0001710214,0.9584688,0.001324886,0.0007774402,0.02549287],"study_design_scores_gemma":[0.000805339,0.007783042,0.206646,0.0002540649,0.0003035369,0.04768417,0.0005537076,0.002136184,0.6768106,0.006621405,0.05029884,0.0001030508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9547367,0.03193802,0.007226072,0.0006678076,0.000176055,0.00009620016,0.0004559057,0.0001690645,0.004534187],"genre_scores_gemma":[0.991402,0.005502121,0.001440582,0.0002865768,0.00004890437,0.00004314203,0.0002657956,0.00001346954,0.0009975156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001644742,"threshold_uncertainty_score":0.005502164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006883855255316237,"score_gpt":0.2135023115159166,"score_spread":0.2066184562606004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}