{"id":"W3178256367","doi":"10.3389/fnagi.2021.672077","title":"Association of Tau Pathology With Clinical Symptoms in the Subfields of Hippocampal Formation","year":2021,"lang":"en","type":"article","venue":"Frontiers in Aging Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; H. Lundbeck A/S; Natural Science Foundation of Jiangsu Province; National Natural Science Foundation of China; Eisai; Servier; Government of Jiangsu Province; Genentech; IXICO; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Hippocampal formation; Subiculum; Entorhinal cortex; Tauopathy; Dentate gyrus; Hippocampus; Parahippocampal gyrus; Psychology; Apolipoprotein E; Alzheimer's disease; Neuroscience; Temporal lobe; Internal medicine; Cognition; Medicine; Oncology; Neurodegeneration; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002712681,0.0004102378,0.0002415856,0.0006449014,0.0002927674,0.0003704373,0.0001551039,0.0003339635,0.001692796],"category_scores_gemma":[0.001363985,0.0001689336,0.0001532086,0.0002761316,0.000367278,0.00026647,0.0002909173,0.0002449926,0.0002090857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001154308,"about_ca_system_score_gemma":0.0001672767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00106775,"about_ca_topic_score_gemma":0.00167422,"domain_scores_codex":[0.9998471,0.00002788958,0.00002112122,0.00004797885,0.00003337182,0.00002261731],"domain_scores_gemma":[0.9991753,0.0001164229,0.0004023029,0.00003921305,0.00009732091,0.0001694275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005268066,0.00004965337,0.9955088,0.00001492389,0.00004773165,0.0002691195,0.0001006562,0.00002308576,0.001954446,0.0000114857,0.00006622126,0.001427164],"study_design_scores_gemma":[0.00001126548,0.0001089392,0.9982894,0.000003638155,0.00001198965,0.001196736,0.0000947431,0.00005836629,0.000150245,0.00002452755,0.00004850578,0.00000154074],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995922,0.0001468553,0.0000375485,0.00001144587,0.0000026597,0.000004038576,0.00004220318,0.000001970664,0.0001611082],"genre_scores_gemma":[0.9996954,0.00004357119,0.00004578571,0.00000811993,0.000006465332,0.00000356287,0.0001010149,8.567547e-7,0.0000951637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001692796,"threshold_uncertainty_score":0.005662978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02744722934383231,"score_gpt":0.3305482579829968,"score_spread":0.3031010286391645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}