{"id":"W3178256367","doi":"10.3389/fnagi.2021.672077","title":"Association of Tau Pathology With Clinical Symptoms in the Subfields of Hippocampal Formation","year":2021,"lang":"en","type":"article","venue":"Frontiers in Aging Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; H. Lundbeck A/S; Natural Science Foundation of Jiangsu Province; National Natural Science Foundation of China; Eisai; Servier; Government of Jiangsu Province; Genentech; IXICO; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Hippocampal formation; Subiculum; Entorhinal cortex; Tauopathy; Dentate gyrus; Hippocampus; Parahippocampal gyrus; Psychology; Apolipoprotein E; Alzheimer's disease; Neuroscience; Temporal lobe; Internal medicine; Cognition; Medicine; Oncology; Neurodegeneration; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000584871,0.00004756168,0.000168985,0.00009100511,0.00002157518,0.000006598605,0.00009058727,0.0000388962,0.000001894481],"category_scores_gemma":[0.0004453246,0.00003211439,0.00003446082,0.0004712497,0.0001246875,0.000102067,0.00002228373,0.000161791,3.486192e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004217833,"about_ca_system_score_gemma":0.0001620997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000095613,"about_ca_topic_score_gemma":0.00001274337,"domain_scores_codex":[0.9988771,0.0002336118,0.0002310346,0.0001484412,0.0003436231,0.0001661915],"domain_scores_gemma":[0.999525,0.0001029641,0.0001122354,0.000159174,0.00006314778,0.0000375232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00005502885,0.0002341472,0.9971114,0.00002107347,0.00002034378,0.0001676214,0.0002989472,0.00001348951,0.000157414,0.00001682657,0.000268589,0.001635105],"study_design_scores_gemma":[0.001123453,0.0002591498,0.9953279,0.00006229904,0.00004115446,0.00002453593,0.0003771743,0.001445162,0.001140842,0.0001401993,0.00002778237,0.00003027907],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969623,0.0003271043,0.001243505,0.0009165792,0.0001787945,0.0001509653,0.000004011326,0.000004051903,0.0002126944],"genre_scores_gemma":[0.9990011,0.0001385141,0.0005430616,0.0002740567,0.0000103147,0.000007332203,0.000005253155,0.000002681265,0.00001763707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002038855,"threshold_uncertainty_score":0.1309587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02744722934383231,"score_gpt":0.3305482579829968,"score_spread":0.3031010286391645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}