{"id":"W3178283611","doi":"10.3390/cells10071789","title":"Amyotrophic Lateral Sclerosis (ALS): Stressed by Dysfunctional Mitochondria-Endoplasmic Reticulum Contacts (MERCs)","year":2021,"lang":"en","type":"review","venue":"Cells","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Endoplasmic reticulum; Mitochondrion; Cell biology; Unfolded protein response; Amyotrophic lateral sclerosis; Autophagy; Neurodegeneration; SOD1; Mitophagy; Biology; Oxidative stress; Chaperone (clinical); Chemistry; Biochemistry; Medicine; Apoptosis; Pathology; Superoxide dismutase; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003635967,0.0009449291,0.001127345,0.002248079,0.0003078276,0.001117231,0.0007891392,0.001104229,0.003572313],"category_scores_gemma":[0.0004996462,0.0001737084,0.0003719795,0.002139482,0.0004373188,0.001301904,0.0007861415,0.00146734,0.003152173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005222753,"about_ca_system_score_gemma":0.000866705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007552329,"about_ca_topic_score_gemma":0.001446139,"domain_scores_codex":[0.9998695,0.0000206467,0.00002204276,0.00002457399,0.00004844606,0.0000148468],"domain_scores_gemma":[0.9998195,0.000060562,0.00003069671,0.00000762431,0.0000529066,0.00002866388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006448271,0.00004425155,0.0001470082,0.01267156,0.00006858469,0.0002428007,0.00005293238,0.0001912372,0.001384362,0.0031977,0.03951292,0.9424222],"study_design_scores_gemma":[0.00001244077,0.00005369903,0.0005822706,0.002725548,0.00008487687,0.001834582,0.00004741957,0.0000400298,0.0002681541,0.001310921,0.9930289,0.0000110978],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008921084,0.9984084,0.00008394437,0.000204898,0.0002089117,0.000002980119,0.00001625104,0.00001025704,0.0009751634],"genre_scores_gemma":[0.000684078,0.9981933,0.0001219379,0.0001593668,0.0001515438,0.000004019719,0.00004047367,0.000001512915,0.0006437362],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003572313,"threshold_uncertainty_score":0.01195061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06228240484682158,"score_gpt":0.3184954598573829,"score_spread":0.2562130550105613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}