{"id":"W3178283611","doi":"10.3390/cells10071789","title":"Amyotrophic Lateral Sclerosis (ALS): Stressed by Dysfunctional Mitochondria-Endoplasmic Reticulum Contacts (MERCs)","year":2021,"lang":"en","type":"review","venue":"Cells","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Endoplasmic reticulum; Mitochondrion; Cell biology; Unfolded protein response; Amyotrophic lateral sclerosis; Autophagy; Neurodegeneration; SOD1; Mitophagy; Biology; Oxidative stress; Chaperone (clinical); Chemistry; Biochemistry; Medicine; Apoptosis; Pathology; Superoxide dismutase; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.000296024,0.001157324,0.003928873,0.000376808,0.0002374299,0.0002692838,0.0005936144,0.001171604,0.006744651],"category_scores_gemma":[0.0001796038,0.0009186598,0.001472576,0.0009067513,0.0003056063,0.0001876213,0.0003893996,0.002143398,0.002380155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007225569,"about_ca_system_score_gemma":0.001204321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001354022,"about_ca_topic_score_gemma":0.00000731606,"domain_scores_codex":[0.9933502,0.0006560281,0.001449496,0.00160977,0.001569262,0.001365229],"domain_scores_gemma":[0.9963183,0.0004360263,0.0005094146,0.00136969,0.0004273112,0.000939202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003110433,0.001787397,0.00007071916,0.04092796,0.00390931,0.001686455,0.0001069759,0.000007153012,0.03558915,0.0001279825,0.552358,0.3631178],"study_design_scores_gemma":[0.001909152,0.0003450662,0.00008293864,0.02734795,0.001555118,0.0001714041,0.000008465214,0.00001986512,0.001427464,0.000006448658,0.9662856,0.0008405111],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002794319,0.9909127,0.00001779855,0.0003542064,0.001797974,0.002179627,0.0006152004,0.0001715447,0.001156663],"genre_scores_gemma":[0.000562878,0.9727499,0.0002820961,0.0003276439,0.001157355,0.0003749782,0.002878823,0.0002892971,0.02137702],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4139276,"threshold_uncertainty_score":0.9993264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06228240484682158,"score_gpt":0.3184954598573829,"score_spread":0.2562130550105613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}