{"id":"W3178291929","doi":"10.1101/gr.270066.120","title":"Hydroxycarbamide effects on DNA methylation and gene expression in myeloproliferative neoplasms","year":2021,"lang":"en","type":"article","venue":"Genome Research","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Comisión Nacional de Investigación Científica y Tecnológica; Medical Research Council; Agencia Nacional de Investigación y Desarrollo; Medical Research Council Canada; King's Health Partners; King's College London; National Institute for Health and Care Research; European Hematology Association","keywords":"Biology; DNA methylation; Transcriptome; RUNX1; Methylation; Haematopoiesis; Gene; Transcription factor; Cell cycle; Gene expression profiling; Gene expression; Genetics; Transcription (linguistics); Cancer research; Stem cell; Cell biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008463023,0.0002147587,0.0004321358,0.0004130554,0.0002051609,0.00006506737,0.00006068437,0.0001487263,0.0001139869],"category_scores_gemma":[0.0005786585,0.0001723116,0.00005953181,0.0006399793,0.00008072172,0.00008364768,0.0001389438,0.000533997,0.0001156186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003282893,"about_ca_system_score_gemma":0.0002822543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002155751,"about_ca_topic_score_gemma":0.00004141083,"domain_scores_codex":[0.9970756,0.00065731,0.0002776366,0.0006744278,0.0007803621,0.0005346608],"domain_scores_gemma":[0.9979735,0.001032556,0.00003820894,0.0003809627,0.000300715,0.0002740517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005617553,0.0006628613,0.04432416,0.0002539621,0.0001140141,0.001790628,0.001936284,0.00006557473,0.9345082,0.0007013946,0.0002009527,0.01488019],"study_design_scores_gemma":[0.002245503,0.0007792561,0.2447975,0.000234962,0.00001477613,0.00004960087,0.000130879,0.0001032436,0.7500007,0.0006057229,0.0009162608,0.0001216722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897365,0.003457368,0.00003307433,0.002337357,0.000056291,0.001045381,0.000009953252,0.00002512937,0.003298942],"genre_scores_gemma":[0.9944568,0.001561231,0.001857724,0.0002378233,0.0001965269,0.0004265847,0.0001030188,0.00003322513,0.001127038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2004733,"threshold_uncertainty_score":0.7026663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04670132125271869,"score_gpt":0.3575508120768331,"score_spread":0.3108494908241144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}