{"id":"W3178291929","doi":"10.1101/gr.270066.120","title":"Hydroxycarbamide effects on DNA methylation and gene expression in myeloproliferative neoplasms","year":2021,"lang":"en","type":"article","venue":"Genome Research","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Comisión Nacional de Investigación Científica y Tecnológica; Medical Research Council; Agencia Nacional de Investigación y Desarrollo; Medical Research Council Canada; King's Health Partners; King's College London; National Institute for Health and Care Research; European Hematology Association","keywords":"Biology; DNA methylation; Transcriptome; RUNX1; Methylation; Haematopoiesis; Gene; Transcription factor; Cell cycle; Gene expression profiling; Gene expression; Genetics; Transcription (linguistics); Cancer research; Stem cell; Cell biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008487034,0.0001381064,0.0001529169,0.0002055111,0.0001065821,0.0001455416,0.00007338139,0.0001438342,0.0008031838],"category_scores_gemma":[0.0001153613,0.00007150324,0.0001237651,0.0001530759,0.0001333526,0.00008187286,0.00009649847,0.0002400249,0.00008279065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001816629,"about_ca_system_score_gemma":0.0001175875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007863966,"about_ca_topic_score_gemma":0.00131998,"domain_scores_codex":[0.9999164,0.00001496386,0.000005034331,0.00002857283,0.00001984977,0.00001506567],"domain_scores_gemma":[0.9999431,0.00001084273,0.00001692346,0.000006517095,0.000009581237,0.00001302406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000346934,0.00002676551,0.001425712,0.00003540988,0.00001115928,0.00003131002,0.00002713215,0.00007669958,0.993887,0.00002072644,0.00004110307,0.004070164],"study_design_scores_gemma":[0.00003557746,0.001274593,0.1298407,0.00001557165,0.00005563152,0.0003167457,0.0001050088,0.0007301564,0.8631991,0.00008317429,0.004335095,0.000008514675],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935024,0.004770587,0.0005234124,0.00005230019,0.00001598102,0.0000144415,0.0004977584,0.00002977878,0.0005933571],"genre_scores_gemma":[0.9966233,0.00134483,0.0005264279,0.00004393759,0.000008672989,0.00002708838,0.0006047151,0.000006840547,0.0008141562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008031838,"threshold_uncertainty_score":0.002686858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04670132125271869,"score_gpt":0.3575508120768331,"score_spread":0.3108494908241144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}