{"id":"W3178297439","doi":"10.4049/jimmunol.2000498","title":"Dendritic Cells Require TMEM176A/B Ion Channels for Optimal MHC Class II Antigen Presentation to Naive CD4+ T Cells","year":2021,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Université de Recherche Paris Sciences et Lettres; Conseil Régional des Pays de la Loire; Centre National de la Recherche Scientifique; Fondation pour la Recherche Médicale; Agence Nationale de la Recherche; Labex CelTisPhyBio; Infrastructures en Biologie Santé et Agronomie","keywords":"Antigen presentation; MHC class II; Cell biology; Priming (agriculture); Antigen processing; Antigen-presenting cell; MHC class I; Biology; CD1D; CD8; CD1; Dendritic cell; T cell; Antigen; Immune system; Immunology; Natural killer T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001178952,0.0003036359,0.0002076153,0.0001071931,0.0001259153,0.0002919791,0.0001650266,0.0003333068,0.001143179],"category_scores_gemma":[0.0001094673,0.0001271314,0.0001934218,0.00008040297,0.0002202667,0.0003448907,0.0002328606,0.0005629186,0.0005565666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001818384,"about_ca_system_score_gemma":0.0001624366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001868818,"about_ca_topic_score_gemma":0.0001462707,"domain_scores_codex":[0.9998751,0.00001636433,0.00001132136,0.00002649061,0.00002892228,0.00004176968],"domain_scores_gemma":[0.9998651,0.00001230103,0.00005228139,0.00001718727,0.00001730869,0.0000358029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004866866,0.000002830655,0.00008538066,0.00000823588,8.649392e-7,0.00001698764,0.000002564865,0.000013103,0.9996406,0.00003688141,0.000006423567,0.0001375223],"study_design_scores_gemma":[0.00002775343,0.0001503327,0.00551795,0.000006321574,0.000009591878,0.0003363625,0.00006146889,0.0005886722,0.9915976,0.0001134601,0.001586172,0.000004284961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960817,0.0005263711,0.002277072,0.00007992892,0.00002379745,0.00001821637,0.0003052865,0.00004863605,0.0006390931],"genre_scores_gemma":[0.9965795,0.0002810084,0.001918035,0.00004420118,0.000009713952,0.00001947225,0.0002352719,0.0000199108,0.000892868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001143179,"threshold_uncertainty_score":0.003824353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0167743083510772,"score_gpt":0.2693071719022123,"score_spread":0.2525328635511351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}