{"id":"W3178309154","doi":"10.1158/1538-7445.am2021-1005","title":"Abstract 1005: The bispecific antibody zanidatamab's (ZW25's) unique mechanisms of action and durable anti-tumor activity in HER2-expressing cancers","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Zymeworks (Canada)","funders":"","keywords":"Pertuzumab; Antibody; Antibody-dependent cell-mediated cytotoxicity; Cancer research; Trastuzumab; Internalization; Humanized antibody; Cancer; Medicine; Epidermal growth factor receptor; Receptor; Immunology; Breast cancer; Monoclonal antibody; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001873117,0.0004092824,0.0002211111,0.0003852931,0.0001632421,0.0004546994,0.0004680873,0.0003487936,0.004664562],"category_scores_gemma":[0.0001053843,0.0001111829,0.0001968544,0.0002725828,0.0001769829,0.0002665813,0.0001953973,0.0006221006,0.001300199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006055459,"about_ca_system_score_gemma":0.0005187357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001675465,"about_ca_topic_score_gemma":0.002749006,"domain_scores_codex":[0.9999197,0.00001072278,0.000006364484,0.00001562335,0.0000247744,0.00002286446],"domain_scores_gemma":[0.9999732,0.000002073435,0.000007617103,0.00000158314,0.000005022292,0.00001055719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004030489,0.0006694841,0.001774654,0.0006220312,0.0001069946,0.0006965793,0.00005376284,0.001303278,0.6542848,0.003294097,0.02244115,0.3107227],"study_design_scores_gemma":[0.005573191,0.01133745,0.02189398,0.0001668108,0.000377657,0.00696828,0.00006602281,0.004251819,0.6616344,0.0009317854,0.2867497,0.00004889923],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8615943,0.08262559,0.008961781,0.002865494,0.001132545,0.0006339966,0.002629447,0.0008372368,0.03871953],"genre_scores_gemma":[0.9539193,0.01849285,0.00362612,0.0008903523,0.0002038802,0.0001683953,0.002534559,0.00004700558,0.02011756],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004664562,"threshold_uncertainty_score":0.01560456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1126481908267863,"score_gpt":0.4419157117249375,"score_spread":0.3292675208981513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}