{"id":"W3178312088","doi":"10.1016/j.taap.2021.115642","title":"The interaction of disulfiram and H2S metabolism in inhibition of aldehyde dehydrogenase activity and liver cancer cell growth","year":2021,"lang":"en","type":"article","venue":"Toxicology and Applied Pharmacology","topic":"Sulfur Compounds in Biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal; Laurentian University","funders":"Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Aldehyde dehydrogenase; Disulfiram; Cancer cell; Liver cancer; Cancer stem cell; Chemistry; Cancer; Cell growth; Cancer research; Biochemistry; Cell; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001903341,0.0001244389,0.0002388526,0.00003134301,0.00006948385,0.000003960712,0.00005396176,0.0002255366,0.00003236689],"category_scores_gemma":[0.00002066219,0.0001071746,0.00002432154,0.00006507823,0.0004940952,0.000006139428,0.000210215,0.0001507888,2.367767e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001184152,"about_ca_system_score_gemma":0.00005682651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005909398,"about_ca_topic_score_gemma":0.0004551793,"domain_scores_codex":[0.9990759,0.0002021154,0.0002021869,0.0003053522,0.00003341247,0.0001809977],"domain_scores_gemma":[0.9995044,0.0001713853,0.000140152,0.00009178745,0.00004805272,0.00004419898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005847396,0.000144004,0.001411206,0.00004323779,0.00006728812,0.000005019048,0.00009893368,0.000009468608,0.9934883,0.0006154275,0.0001202197,0.003412196],"study_design_scores_gemma":[0.001310893,0.0001173662,0.009910581,0.000003319867,0.00006267858,0.00003805935,0.0001131178,0.00007608119,0.9865372,0.0003350953,0.001400342,0.00009530591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924154,0.006533152,0.00003235209,0.0002406695,0.0001968671,0.0001789213,0.00001707569,0.000003399181,0.0003822214],"genre_scores_gemma":[0.988376,0.01101542,0.0001085443,0.0003083772,0.00007271636,0.00007327733,0.00001293389,0.000008392377,0.00002434785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008499375,"threshold_uncertainty_score":0.4370455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01109923637573308,"score_gpt":0.281175985945543,"score_spread":0.2700767495698099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}