{"id":"W3178324475","doi":"10.1186/s13041-021-00817-3","title":"Disrupting the α7nAChR–NR2A protein complex exerts antidepressant-like effects","year":2021,"lang":"en","type":"article","venue":"Molecular Brain","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research","keywords":"Psychopharmacology; Antidepressant; Neuroscience; Psychology; Psychiatry; Hippocampus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001594004,0.0004042855,0.0004442381,0.0001421005,0.0001335038,0.0002455504,0.0002119488,0.0003033593,0.000891675],"category_scores_gemma":[0.000127704,0.0001130849,0.0003264825,0.00009145326,0.0002056169,0.0001310208,0.0001166526,0.0005817605,0.0003995358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002115543,"about_ca_system_score_gemma":0.0001432487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005126331,"about_ca_topic_score_gemma":0.001431955,"domain_scores_codex":[0.9998247,0.00003376412,0.00001927345,0.0000291753,0.00006149791,0.00003158542],"domain_scores_gemma":[0.9999312,0.000006909322,0.00002464691,0.000008483985,0.00001102515,0.00001778658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001190563,0.00004261078,0.0001410681,0.00003325694,0.00001750889,0.00003798347,0.000003972357,0.00002924797,0.9979753,0.00004344987,0.0000623846,0.001494118],"study_design_scores_gemma":[0.00007487047,0.00256784,0.0134891,0.00001872915,0.0001058148,0.000836037,0.00004090285,0.001208348,0.9765837,0.0001004446,0.004965158,0.000008972961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880575,0.005605261,0.003199375,0.0002862836,0.0001382708,0.00003887753,0.0002901543,0.000122901,0.002261422],"genre_scores_gemma":[0.9921043,0.002837192,0.002380281,0.000138545,0.00002730267,0.00003105208,0.0005517555,0.00001609413,0.001913448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000891675,"threshold_uncertainty_score":0.002982974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04130677070081522,"score_gpt":0.3405742603422058,"score_spread":0.2992674896413906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}