{"id":"W3178327715","doi":"10.1093/nar/gkab574","title":"Diverse high-affinity DNA aptamers for wild-type and B.1.1.7 SARS-CoV-2 spike proteins from a pre-structured DNA library","year":2021,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; McMaster University","keywords":"Aptamer; Biology; Molecular biology; DNA; Protein subunit; DNA sequencing; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004027529,0.000702858,0.0005970158,0.0005396517,0.0001620341,0.0002815298,0.0003525656,0.0005245101,0.001046622],"category_scores_gemma":[0.0004729804,0.0003368008,0.0003582192,0.0003686139,0.0002179079,0.0001611103,0.0002750585,0.0005603785,0.0007160358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000341081,"about_ca_system_score_gemma":0.0002372925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004576001,"about_ca_topic_score_gemma":0.001129752,"domain_scores_codex":[0.9994874,0.0001135353,0.00003183328,0.0001213536,0.0001505061,0.00009536801],"domain_scores_gemma":[0.9997831,0.00006520482,0.00002942708,0.00001957864,0.00005367025,0.00004909429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004216814,0.00003124202,0.0001387294,0.00001807898,0.000004040942,0.00001256076,0.00001064186,0.0001833988,0.998449,0.00001404421,0.0000153273,0.00108074],"study_design_scores_gemma":[0.00002255312,0.0008185869,0.001813799,0.000004162353,0.00002469343,0.0001884162,0.00001941136,0.003274986,0.992912,0.00003359251,0.0008782427,0.000009448818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820222,0.0007133649,0.01553808,0.00009618549,0.00002396873,0.0001942017,0.000313464,0.0001784205,0.0009201541],"genre_scores_gemma":[0.9596013,0.0005094243,0.03425518,0.0002087493,0.00001843643,0.0002267671,0.001887252,0.0000533455,0.003239556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001046622,"threshold_uncertainty_score":0.003501296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03627738058881245,"score_gpt":0.3350864100096514,"score_spread":0.298809029420839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}