{"id":"W3178399873","doi":"10.1101/2021.07.14.451536","title":"Palmitoylation targets the Calcineurin phosphatase to the Phosphatidylinositol 4-kinase complex at the plasma membrane","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital; University of British Columbia; Lunenfeld-Tanenbaum Research Institute; University of Victoria","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Natural Sciences and Engineering Research Council of Canada; National Institute of Child Health and Human Development; Canadian Institutes of Health Research; Nemzeti Kutatási, Fejlesztési és Innovaciós Alap; National Institutes of Health; Michael Smith Health Research BC","keywords":"Calcineurin; Palmitoylation; Phosphatase; Cell biology; Biology; Biochemistry; Phosphatidylinositol; Pleckstrin homology domain; Kinase; Phosphorylation; Chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001043534,0.000218629,0.0001085249,0.0001096251,0.0002322832,0.0002657446,0.0001880483,0.0001997217,0.0011449],"category_scores_gemma":[0.00008057329,0.0001005351,0.0001231675,0.00009855782,0.0002254617,0.0001883117,0.0002383885,0.0003065408,0.0003303549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005312678,"about_ca_system_score_gemma":0.0002106104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009849829,"about_ca_topic_score_gemma":0.001327419,"domain_scores_codex":[0.9999326,0.000009301885,0.000004309033,0.00001953341,0.00001848115,0.0000157399],"domain_scores_gemma":[0.9999632,0.000004817174,0.00001224483,0.000005804385,0.000004196408,0.000009724409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005147699,0.000004613098,0.0001463224,0.0000151221,0.000002703446,0.00004226877,0.000005969895,0.00007716476,0.9988417,0.0002112246,0.00003065517,0.0005709071],"study_design_scores_gemma":[0.00001082696,0.00003465109,0.003222724,0.000003716688,0.000005788293,0.0001940073,0.00001769629,0.001227946,0.9923128,0.0001804297,0.002786322,0.000002981735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907898,0.001328653,0.005351312,0.0002750829,0.0000412274,0.00001575189,0.0002170391,0.00007021731,0.001910957],"genre_scores_gemma":[0.9927746,0.000929443,0.002661075,0.0000708595,0.000008739535,0.00001198122,0.0002700422,0.00001599353,0.003257148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0011449,"threshold_uncertainty_score":0.003854632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01559140989982567,"score_gpt":0.2325823362148979,"score_spread":0.2169909263150722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}