{"id":"W3178421078","doi":"10.3389/fphys.2021.687654","title":"Airway Epithelial Cells Drive Airway Smooth Muscle Cell Phenotype Switching to the Proliferative and Pro-inflammatory Phenotype","year":2021,"lang":"en","type":"article","venue":"Frontiers in Physiology","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Christie (Canada); McGill University Health Centre","funders":"National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; Reseau canadien de recherche respiratoire","keywords":"Epidermal growth factor; Biology; Phenotype; Cell biology; Epidermal growth factor receptor; Epithelium; Cell growth; Transcription factor; Respiratory epithelium; Cancer research; Bromodeoxyuridine; Cell culture; Immunology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001559095,0.0002245587,0.0004344306,0.0001185172,0.0001755788,0.00002367033,0.0001236168,0.0001194823,0.0001208451],"category_scores_gemma":[0.00009318602,0.000166497,0.00009460477,0.0002416859,0.0000872473,0.0000842588,0.0001268693,0.0005079822,0.00005717323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009616075,"about_ca_system_score_gemma":0.0002286124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004873429,"about_ca_topic_score_gemma":0.00006753919,"domain_scores_codex":[0.9984944,0.0001759678,0.0003194775,0.0004989192,0.0001397545,0.0003714947],"domain_scores_gemma":[0.9991587,0.00008473916,0.0001020798,0.0003748228,0.000150626,0.0001290442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002788727,0.0001737672,0.0006460611,0.00006330959,0.00004968835,0.00002872079,0.004319635,0.0003329587,0.9752591,0.0001365373,0.01108431,0.007627028],"study_design_scores_gemma":[0.003291097,0.001273259,0.05231762,0.0002577279,0.0001833677,0.00001342867,0.005462037,0.005406665,0.7768053,0.001967977,0.1523409,0.0006806599],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988291,0.0004638474,0.004676859,0.001575343,0.002111741,0.0007488595,0.00002882442,0.00005014098,0.002053426],"genre_scores_gemma":[0.9922519,0.00007968506,0.004725484,0.00153919,0.0006924652,0.00008574945,0.00002478115,0.00003779041,0.0005629252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1984538,"threshold_uncertainty_score":0.678955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009441658579320895,"score_gpt":0.2371652244373067,"score_spread":0.2277235658579858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}