{"id":"W3178452461","doi":"10.1093/nar/gkab549","title":"Combinatorial analysis of translation dynamics reveals eIF2 dependence of translation initiation at near-cognate codons","year":2021,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Biology; Translation (biology); Eukaryotic translation; Ribosome profiling; Computational biology; eIF2; Initiation factor; Translational regulation; Genetics; Start codon; Eukaryotic initiation factor; Ribosome; Messenger RNA; Gene; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002288259,0.0003280519,0.0004499082,0.000549448,0.0002838254,0.0004704047,0.0001953433,0.0002192547,0.0007695522],"category_scores_gemma":[0.0002983826,0.0001891605,0.0003875291,0.0004035704,0.0001908901,0.0002759421,0.0002322951,0.0007416328,0.0003551918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004689012,"about_ca_system_score_gemma":0.0002163662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005127914,"about_ca_topic_score_gemma":0.001473796,"domain_scores_codex":[0.9998255,0.0000135769,0.00001476552,0.00006276697,0.00005093068,0.00003247859],"domain_scores_gemma":[0.9997723,0.00007423654,0.00004849987,0.00002110892,0.00003792829,0.00004599282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008553736,0.00001118525,0.0006890121,0.00002786629,0.000006484674,0.00001554476,0.000008595878,0.0001557425,0.9978136,0.00007450029,0.00003598262,0.001075878],"study_design_scores_gemma":[0.000009994777,0.0000760616,0.01639126,0.000005714602,0.00002551297,0.00008458034,0.00003250483,0.01373795,0.9680702,0.0001907739,0.001355969,0.00001942322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98413,0.0007240125,0.01250394,0.0000471718,0.00002787394,0.00002544961,0.001430485,0.0002742517,0.0008368207],"genre_scores_gemma":[0.9811943,0.0005388155,0.01443904,0.00005963993,0.00001207441,0.00006485687,0.002527306,0.0001616254,0.00100231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007695522,"threshold_uncertainty_score":0.003402114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04999809679998395,"score_gpt":0.3356130363144696,"score_spread":0.2856149395144856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}