{"id":"W3178543062","doi":"10.1158/1538-7445.am2021-2114","title":"Abstract 2114: Horvath clock as a predictor of cancer risk in LFS patients","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"dNaM; Epigenetics; DNA methylation; Cancer; Oncology; Medicine; Disease; Biomarker; Age of onset; Germline mutation; Genetics; Internal medicine; Biology; Mutation; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000432563,0.0002297383,0.0003087175,0.0008197427,0.0002715807,0.000477483,0.0002739556,0.000328772,0.003369833],"category_scores_gemma":[0.002659874,0.0001089207,0.0004168365,0.0008961444,0.00011105,0.0001850166,0.0002687156,0.0005448756,0.000600778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000272949,"about_ca_system_score_gemma":0.0002439447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002410674,"about_ca_topic_score_gemma":0.001760616,"domain_scores_codex":[0.99979,0.00005628405,0.00002243835,0.00005543566,0.00004083575,0.00003498842],"domain_scores_gemma":[0.9990037,0.0002988595,0.0003249715,0.00005887284,0.0001104314,0.0002031519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006082666,0.00002844138,0.9910259,0.00001959868,0.00004661485,0.0001016966,0.00003493116,0.0001330375,0.0006923117,0.00003752244,0.0007501952,0.006521545],"study_design_scores_gemma":[0.00003161381,0.0002526767,0.9946063,0.00001688465,0.00008275226,0.00047786,0.0001143973,0.002131246,0.0008213922,0.0001174604,0.001335594,0.00001182807],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958706,0.0008273357,0.0006280526,0.0001899953,0.00007049015,0.00001402771,0.001513097,0.00005403724,0.0008321598],"genre_scores_gemma":[0.9979504,0.0001332367,0.0006895132,0.00005347698,0.00002742853,0.00001935065,0.000652382,0.0000140534,0.0004601682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003369833,"threshold_uncertainty_score":0.01127321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03475428221287721,"score_gpt":0.3940819517069354,"score_spread":0.3593276694940583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}