{"id":"W3178554101","doi":"10.1096/fasebj.31.1_supplement.1065.12","title":"Compartmentalized Regulation of Vascular Endothelial Cell Responses to Fluid Shear Stress by Phosphodiesterase 4D7 (PDE4D7)","year":2017,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Gene knockdown; Cell biology; Adherens junction; Rap1; Chemistry; Phosphodiesterase; Biophysics; Biology; Cell; Signal transduction; Biochemistry; Cadherin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001384791,0.0001635074,0.0003589588,0.0001158916,0.0005763574,0.0001024848,0.0005000044,0.000101532,0.0008611709],"category_scores_gemma":[0.0009247185,0.0001016644,0.0001868551,0.00009018027,0.000396643,0.0001105879,0.0001620354,0.000490572,0.0001032586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001264776,"about_ca_system_score_gemma":0.0002065943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009961551,"about_ca_topic_score_gemma":0.000002897977,"domain_scores_codex":[0.9975418,0.0002825528,0.0004680274,0.0001874983,0.001139979,0.0003800925],"domain_scores_gemma":[0.9980091,0.0003135202,0.0002676075,0.0007265463,0.000204674,0.0004785596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003804488,0.0002821785,0.007171157,0.00003476821,0.0001478154,0.00007996998,0.0004489521,0.00001378518,0.9723668,0.00001313771,0.01335264,0.00228436],"study_design_scores_gemma":[0.005834895,0.0007269473,0.05585026,0.0003409359,0.0001620034,0.0001170296,0.0002974774,0.000420287,0.9274337,0.00007173751,0.008610915,0.0001338468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935223,0.000676851,0.0004458586,0.003754262,0.0002272668,0.0004652647,0.0001004547,0.00001555838,0.0007921193],"genre_scores_gemma":[0.9957006,0.000309428,0.0004832988,0.0003134386,0.0002220299,0.000006906803,0.00002030456,0.00002568962,0.002918327],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0486791,"threshold_uncertainty_score":0.9429218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0299331301030289,"score_gpt":0.3299579155695353,"score_spread":0.3000247854665064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}