{"id":"W3178615988","doi":"10.1093/narcan/zcab028","title":"Characterization of a <i>RAD51C</i> -silenced high-grade serous ovarian cancer model during development of PARP inhibitor resistance","year":2021,"lang":"en","type":"article","venue":"NAR Cancer","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Stand Up To Cancer; National Institutes of Health; Mayo Foundation for Medical Education and Research; Sierra Oncology; National Institute of General Medical Sciences; National Institute for Health and Care Research; Eisai; BeiGene; National Breast Cancer Foundation; Clovis Oncology; Ovarian Cancer Research Alliance; AstraZeneca","keywords":"Cancer research; Ovarian cancer; PARP inhibitor; Methylation; Biology; Medicine; Cancer; Oncology; Internal medicine; Poly ADP ribose polymerase; Gene; Genetics; Polymerase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001852575,0.0002121105,0.0002790747,0.0002784679,0.0001697697,0.0002966874,0.0002137858,0.0002910136,0.001851688],"category_scores_gemma":[0.00009671275,0.0001403106,0.0002678028,0.000190393,0.0002279933,0.0001411283,0.0001696262,0.0007160897,0.0004789344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002979579,"about_ca_system_score_gemma":0.0002139381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009410098,"about_ca_topic_score_gemma":0.001143747,"domain_scores_codex":[0.999836,0.00002077098,0.00001481312,0.00003888987,0.00005233749,0.00003720724],"domain_scores_gemma":[0.9998416,0.00002431446,0.00003746567,0.0000344011,0.00001430953,0.0000479494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001055335,0.0001015383,0.0003292475,0.00001432474,0.000004409093,0.0000723229,0.00002004638,0.00007679067,0.9982667,0.0001478226,0.00008908859,0.0007720917],"study_design_scores_gemma":[0.00005564445,0.001292276,0.009358483,0.000004328882,0.00002601911,0.0005766405,0.00006086783,0.004149118,0.9804391,0.00007942108,0.003951591,0.000006551771],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906456,0.0004813371,0.005368707,0.0001315685,0.00004443279,0.0001422313,0.001201421,0.0001657975,0.0018189],"genre_scores_gemma":[0.9905529,0.000313151,0.002746372,0.00008196033,0.000008221942,0.0001468568,0.001460495,0.00004300514,0.004647077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001851688,"threshold_uncertainty_score":0.006194472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02601494094062143,"score_gpt":0.2916127471130123,"score_spread":0.2655978061723909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}