{"id":"W3178630184","doi":"10.1158/1538-7445.am2021-ct023","title":"Abstract CT023: PATHFINDER: Interim analysis of avapritinib (ava) in patients (pts) with advanced systemic mastocytosis (AdvSM)","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"","keywords":"Medicine; Systemic mastocytosis; Internal medicine; Interim analysis; Midostaurin; Bristol-Myers; Clinical endpoint; Myeloproliferative neoplasm; Gastroenterology; Phases of clinical research; Surgery; Clinical trial; Leukemia; Myelofibrosis; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00448473,0.000975494,0.001741924,0.0003569652,0.0004185297,0.001064905,0.0006673895,0.0009184473,0.006293945],"category_scores_gemma":[0.002665233,0.0004044207,0.002536495,0.0003671507,0.0004228856,0.0008950611,0.0005083324,0.002248957,0.001327056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008228783,"about_ca_system_score_gemma":0.001286329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003991336,"about_ca_topic_score_gemma":0.0008324768,"domain_scores_codex":[0.9989325,0.0004920004,0.0000643162,0.0001945626,0.0001470582,0.0001694928],"domain_scores_gemma":[0.9985434,0.0003596825,0.0003915518,0.0002473903,0.0001282945,0.0003297895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8564423,0.006920513,0.02709881,0.0006930717,0.004098017,0.0002745988,0.0001074895,0.00575991,0.008013506,0.0004461096,0.01303815,0.07710751],"study_design_scores_gemma":[0.3845152,0.4333273,0.1299039,0.0002087567,0.008739998,0.001451344,0.0001112881,0.009212079,0.01006004,0.001984361,0.02036726,0.0001184961],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9638069,0.003175359,0.002988643,0.0008603166,0.0002193349,0.003373008,0.01900985,0.0003377729,0.006228872],"genre_scores_gemma":[0.9686326,0.0005206302,0.002976995,0.0007381229,0.0001391272,0.00377514,0.01895149,0.00006231314,0.004203655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006293945,"threshold_uncertainty_score":0.02371782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0374080084587002,"score_gpt":0.3342781353346859,"score_spread":0.2968701268759857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}