{"id":"W3178692152","doi":"10.1016/j.jtho.2021.06.017","title":"Liquid Biopsy for Advanced NSCLC: A Consensus Statement From the International Association for the Study of Lung Cancer","year":2021,"lang":"en","type":"review","venue":"Journal of Thoracic Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":645,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Janssen Pharmaceuticals; Stand Up To Cancer; EMD Serono; Genentech; European Society for Medical Oncology; Eisai; Daiichi-Sankyo; European School of Oncology; National Institutes of Health; Rosetrees Trust; Cancer Research UK; ANGLE; Mirati Therapeutics; Bayer Fund; Clovis Oncology; Astex Pharmaceuticals; Meso Scale Diagnostics; Les Laboratories Pierre Fabre; Merck Sharp and Dohme; Takeda Pharmaceuticals U.S.A.; Intel Corporation; Exelixis; ACEA Biosciences; Novartis; Celgene; National Cancer Institute; Gilead Sciences; Francis Crick Institute; Stanford University; International Association for the Study of Lung Cancer; Merck; GlaxoSmithKline; Royal Society; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; Pfizer; Boehringer Ingelheim; Amgen; Roche","keywords":"Liquid biopsy; Medicine; Lung cancer; Cancer; Oncology; Adenocarcinoma; Personalized medicine; Biopsy; Precision medicine; Erlotinib; Internal medicine; Bioinformatics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001059835,0.0001720866,0.0008005526,0.00003772544,0.0000765329,0.00002574229,0.0004683669,0.0002151081,0.00001377738],"category_scores_gemma":[0.001059347,0.000102935,0.0004809268,0.00006082267,0.00002962619,0.000001967517,0.0001345516,0.0001887905,1.313212e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004633972,"about_ca_system_score_gemma":0.001627495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004530634,"about_ca_topic_score_gemma":0.000365648,"domain_scores_codex":[0.9983544,0.0001909654,0.0009217056,0.0001962477,0.0001820829,0.0001546345],"domain_scores_gemma":[0.994445,0.001946937,0.002510868,0.0002248093,0.0008365892,0.00003578465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001845051,0.0005474673,0.00007654737,0.0005152818,0.006295354,0.000009140035,0.0002657508,0.0003015696,0.0007733,0.00001894148,0.04028845,0.9490631],"study_design_scores_gemma":[0.0008290156,0.001513896,0.00001195218,0.0006113825,0.00262358,0.00001483714,0.0005326584,0.00002092719,0.0001664695,0.00001168577,0.993557,0.0001066151],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006614865,0.9853637,0.0006583476,0.001489162,0.003331353,0.001362478,0.001156923,9.114759e-7,0.00002226293],"genre_scores_gemma":[0.001306303,0.9953771,0.0007970413,0.0001891303,0.001665089,0.000324724,0.0001427568,0.00002752944,0.000170295],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9532685,"threshold_uncertainty_score":0.4197567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04054507481892194,"score_gpt":0.4672114398090763,"score_spread":0.4266663649901543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}