{"id":"W3178692152","doi":"10.1016/j.jtho.2021.06.017","title":"Liquid Biopsy for Advanced NSCLC: A Consensus Statement From the International Association for the Study of Lung Cancer","year":2021,"lang":"en","type":"review","venue":"Journal of Thoracic Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":645,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Janssen Pharmaceuticals; Stand Up To Cancer; EMD Serono; Genentech; European Society for Medical Oncology; Eisai; Daiichi-Sankyo; European School of Oncology; National Institutes of Health; Rosetrees Trust; Cancer Research UK; ANGLE; Mirati Therapeutics; Bayer Fund; Clovis Oncology; Astex Pharmaceuticals; Meso Scale Diagnostics; Les Laboratories Pierre Fabre; Merck Sharp and Dohme; Takeda Pharmaceuticals U.S.A.; Intel Corporation; Exelixis; ACEA Biosciences; Novartis; Celgene; National Cancer Institute; Gilead Sciences; Francis Crick Institute; Stanford University; International Association for the Study of Lung Cancer; Merck; GlaxoSmithKline; Royal Society; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; Pfizer; Boehringer Ingelheim; Amgen; Roche","keywords":"Liquid biopsy; Medicine; Lung cancer; Cancer; Oncology; Adenocarcinoma; Personalized medicine; Biopsy; Precision medicine; Erlotinib; Internal medicine; Bioinformatics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00508386,0.001253568,0.003459759,0.002922298,0.00039431,0.001661423,0.002278799,0.003035621,0.002040661],"category_scores_gemma":[0.003212046,0.0005051777,0.00193073,0.002134725,0.0007450756,0.002064455,0.001546213,0.004646199,0.002101262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001484144,"about_ca_system_score_gemma":0.004348371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002700073,"about_ca_topic_score_gemma":0.00581217,"domain_scores_codex":[0.9989991,0.0002087793,0.000200435,0.0001425657,0.000361358,0.00008780608],"domain_scores_gemma":[0.997924,0.0007859113,0.0002367418,0.00003942446,0.0008411335,0.0001728054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002320834,0.00007542394,0.0003505376,0.02088192,0.0002692787,0.0001911108,0.0000402062,0.00035104,0.0009975721,0.002176694,0.1506844,0.8237498],"study_design_scores_gemma":[0.0001918992,0.0001612088,0.00193705,0.02272267,0.0007009567,0.001015623,0.0000618514,0.0001584065,0.0004125812,0.002026826,0.9705569,0.00005392892],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005259407,0.9947943,0.0002676914,0.003014263,0.001352415,0.00002109934,0.00007725191,0.00001072611,0.0004097162],"genre_scores_gemma":[0.0003976212,0.9942935,0.0007203403,0.003039331,0.0008594426,0.000036924,0.0002009329,0.0000046248,0.0004471458],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00508386,"threshold_uncertainty_score":0.02688634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04054507481892194,"score_gpt":0.4672114398090763,"score_spread":0.4266663649901543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}