{"id":"W3178704118","doi":"10.1101/2021.07.12.452088","title":"An intestinally secreted host factor promotes microsporidia invasion of <i>C. elegans</i>","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Microsporidia; Infectivity; Microbiology; Pathogen; Obligate; Caenorhabditis elegans; Mutant; Host (biology); Secretion; Caenorhabditis; Colonization; Intracellular parasite; Pseudomonas aeruginosa; Genetics; Intracellular; Gene; Spore; Bacteria; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007853698,0.0003675843,0.0001787344,0.0001964511,0.0001518276,0.0002404711,0.0001951275,0.0002390914,0.0008311471],"category_scores_gemma":[0.00009988592,0.0001183628,0.0002080598,0.00006168718,0.0001853257,0.0001136518,0.000250124,0.0004429503,0.0002257824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003516546,"about_ca_system_score_gemma":0.0001990998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001026408,"about_ca_topic_score_gemma":0.001637053,"domain_scores_codex":[0.9999108,0.000008162912,0.000009568783,0.00002082762,0.00002144769,0.00002912666],"domain_scores_gemma":[0.9998201,0.00002619603,0.00005453378,0.00001308228,0.00002058402,0.00006549367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003171358,0.00001105016,0.0001646066,0.00001360523,0.000001185543,0.00002966098,0.000003758096,0.00002128898,0.999492,0.00001935001,0.00001525485,0.0001964713],"study_design_scores_gemma":[0.000009674517,0.0002628146,0.01533179,0.000009607106,0.00001184699,0.0002374823,0.000039909,0.001420146,0.9814869,0.00002044731,0.001160108,0.000009270395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983816,0.0001707802,0.0005475426,0.00003480663,0.000007408844,0.000007049424,0.0001828671,0.00005811862,0.0006097826],"genre_scores_gemma":[0.9968752,0.0001228177,0.001271136,0.00003249777,0.000003814504,0.00001362476,0.0003414429,0.00002457125,0.001314943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001026408,"threshold_uncertainty_score":0.002780497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01063089300015871,"score_gpt":0.2137569646779716,"score_spread":0.2031260716778129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}