{"id":"W3178736812","doi":"10.1158/1538-7445.am2021-2974","title":"Abstract 2974: Loss of <i>TSC1</i> or <i>TSC2</i> drives lineage infidelity and hamartoma formation in a renal organoid model of angiomyolipoma","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada; Ottawa Hospital","funders":"","keywords":"TSC1; Angiomyolipoma; Biology; TSC2; Organoid; mTORC1; Induced pluripotent stem cell; Lineage markers; Pathology; Cancer research; Cell biology; Kidney; Stem cell; PI3K/AKT/mTOR pathway; Progenitor cell; Genetics; Medicine; Gene; Signal transduction; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001990299,0.0003938708,0.0002545985,0.0004433647,0.0002446705,0.0003827331,0.0003662444,0.0005185133,0.003186701],"category_scores_gemma":[0.0001278773,0.0002424107,0.0003314966,0.0001681768,0.0003845688,0.0002202056,0.0002776731,0.0008284391,0.001138861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003511687,"about_ca_system_score_gemma":0.0003003041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001312319,"about_ca_topic_score_gemma":0.001695481,"domain_scores_codex":[0.9996932,0.00003985935,0.00004463976,0.00006082278,0.0001009949,0.00006061565],"domain_scores_gemma":[0.9995976,0.00006729065,0.0001219624,0.0000428069,0.0000223522,0.0001478428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005812441,0.0000318827,0.00008620045,0.00001450597,0.000003273056,0.000123679,0.00001435334,0.00006899956,0.9990765,0.0001771533,0.00005766471,0.0002877157],"study_design_scores_gemma":[0.000015334,0.000144152,0.0015588,0.000005739932,0.000009485595,0.0004047245,0.00003283661,0.001086536,0.9950082,0.00004164207,0.001687252,0.000005275472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988123,0.000329692,0.005097522,0.0001775122,0.00006612846,0.0000901547,0.001798361,0.0003716419,0.003946032],"genre_scores_gemma":[0.9871595,0.0002250196,0.003149467,0.00006980474,0.000009909931,0.00007326031,0.0008684993,0.000125198,0.008319258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003186701,"threshold_uncertainty_score":0.01066059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0958769667578749,"score_gpt":0.3824289040679051,"score_spread":0.2865519373100303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}