{"id":"W3178780511","doi":"10.1101/2021.07.07.451375","title":"Multivalent designed proteins protect against SARS-CoV-2 variants of concern","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada)","funders":"National Center for Advancing Translational Sciences; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Defense Threat Reduction Agency; Defense Advanced Research Projects Agency; Open Philanthropy Project; Damon Runyon Cancer Research Foundation; U.S. Department of Defense; European Commission; National Institute of Diabetes and Digestive and Kidney Diseases; Bill and Melinda Gates Foundation; Fast Grants; National Institutes of Health; U.S. Department of Health and Human Services; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; David and Lucile Packard Foundation; National Defense Science and Engineering Graduate; Burroughs Wellcome Fund","keywords":"Coronavirus disease 2019 (COVID-19); Trimer; Computational biology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Pandemic; Spike Protein; 2019-20 coronavirus outbreak; Chemistry; Cell biology; Nanotechnology; Biophysics; Biology; Virology; Medicine; Materials science; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003388476,0.0004151984,0.000272885,0.0001712329,0.0001572345,0.0004418835,0.0003198159,0.0003550336,0.00259541],"category_scores_gemma":[0.000228293,0.0001331803,0.0002684355,0.000102191,0.0001532678,0.0002282785,0.0002531634,0.00045946,0.001021364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000387202,"about_ca_system_score_gemma":0.0002339098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000241752,"about_ca_topic_score_gemma":0.0003858015,"domain_scores_codex":[0.9998931,0.00001407989,0.00000943842,0.0000172545,0.00004567146,0.00002057355],"domain_scores_gemma":[0.9999146,0.00001008656,0.00001810355,0.000007397624,0.0000281684,0.00002165988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002039757,0.00005873228,0.0004395249,0.00009221434,0.00001641047,0.00009740248,0.0000297639,0.0004988584,0.9895043,0.0006059332,0.001120517,0.007332293],"study_design_scores_gemma":[0.00004388107,0.0006086584,0.0009383028,0.00001017306,0.00003218891,0.0003428117,0.00003023675,0.001472729,0.9777257,0.0002089842,0.01857342,0.00001306256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9357505,0.006180092,0.04624921,0.0016203,0.000598889,0.0003333971,0.00127571,0.0006138278,0.007377918],"genre_scores_gemma":[0.9304792,0.003142393,0.04237319,0.0009162206,0.0001165691,0.0001002586,0.001943581,0.0001425663,0.02078592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00259541,"threshold_uncertainty_score":0.008682489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05651244578895582,"score_gpt":0.30965442030127,"score_spread":0.2531419745123142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}