{"id":"W3178864027","doi":"10.1158/1538-7445.am2021-lb098","title":"Abstract LB098: Vulnerability of <i>MTAP</i>-deleted nasopharyngeal carcinoma to MAT2A inhibition","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"CDKN2A; Cancer research; Biology; Synthetic lethality; Cancer; Nasopharyngeal carcinoma; Gene; Copy-number variation; Genetics; Medicine; Genome; Internal medicine; Radiation therapy; DNA repair","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001123305,0.0002523125,0.0002660204,0.0001437465,0.0001723908,0.0002673607,0.0002539144,0.0002608725,0.00290925],"category_scores_gemma":[0.0001376771,0.00008165003,0.0002586853,0.0001377928,0.0001540434,0.0001168245,0.0001790857,0.0005495975,0.001025582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002611624,"about_ca_system_score_gemma":0.0001832103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001598698,"about_ca_topic_score_gemma":0.001114545,"domain_scores_codex":[0.999893,0.00001324477,0.00001200006,0.00002395101,0.00003295793,0.00002477827],"domain_scores_gemma":[0.9999312,0.00001228075,0.00001552245,0.00001098196,0.000007967823,0.00002208214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001218947,0.00003788706,0.0002677491,0.00002710619,0.000007487291,0.0001277844,0.000007001141,0.00009072803,0.9972722,0.00006323124,0.0002691952,0.00170781],"study_design_scores_gemma":[0.00001854112,0.0004334551,0.005933673,0.000005818009,0.00002296032,0.0008814732,0.00002361866,0.001512419,0.9864773,0.00004589024,0.004637561,0.000007416153],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892992,0.001185826,0.002458815,0.0002041492,0.00008817101,0.00004470813,0.002660936,0.0004858724,0.003572374],"genre_scores_gemma":[0.9925114,0.0003695976,0.0008294169,0.0001023109,0.000006764515,0.00004196481,0.002451975,0.00006462743,0.003622038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00290925,"threshold_uncertainty_score":0.009732366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0446867601349072,"score_gpt":0.3708842069069306,"score_spread":0.3261974467720234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}