{"id":"W3178882185","doi":"10.3390/cancers13143488","title":"Development of an Androgen Receptor Inhibitor Targeting the N-Terminal Domain of Androgen Receptor for Treatment of Castration Resistant Prostate Cancer","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Androgen receptor; Prostate cancer; FOXA1; Cancer research; Androgen; Transcription factor; Androgen deprivation therapy; Chemistry; Prostate; Endocrinology; Internal medicine; Biology; Medicine; Cancer; Gene; Hormone; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002392757,0.0001661071,0.0004221961,0.00004897494,0.0001124166,0.000008293416,0.00006803389,0.00006518729,0.0001165842],"category_scores_gemma":[0.00002534995,0.0001095987,0.0001145743,0.0002371917,0.0001631834,0.00006789318,0.00001868083,0.00004572055,6.108307e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001378847,"about_ca_system_score_gemma":0.004308873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001941299,"about_ca_topic_score_gemma":0.0002764264,"domain_scores_codex":[0.9985437,0.00006121322,0.0005231947,0.0002854247,0.0003112778,0.0002751323],"domain_scores_gemma":[0.9988914,0.00005016745,0.0002737036,0.0002248748,0.0004453483,0.00011449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005588807,0.0002349466,0.002214649,0.0007522407,0.0005198914,0.00002346558,0.01352341,0.00004755274,0.9171919,0.00002248658,0.0005670359,0.05931368],"study_design_scores_gemma":[0.00380929,0.001206236,0.000263659,0.000336342,0.000108921,0.000006040358,0.004842371,0.00003860902,0.9619413,0.00001411332,0.02732803,0.000105087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930392,0.004731814,0.00001429984,0.0003142337,0.0001689453,0.00120795,0.0004478781,0.000009182997,0.00006647703],"genre_scores_gemma":[0.9750561,0.001932803,0.02015553,0.00002378895,0.0002591597,0.0008627495,0.0007072947,0.00004569713,0.0009569118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0592086,"threshold_uncertainty_score":0.7643755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03430529043387877,"score_gpt":0.3280932132275991,"score_spread":0.2937879227937203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}