{"id":"W3178882185","doi":"10.3390/cancers13143488","title":"Development of an Androgen Receptor Inhibitor Targeting the N-Terminal Domain of Androgen Receptor for Treatment of Castration Resistant Prostate Cancer","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Androgen receptor; Prostate cancer; FOXA1; Cancer research; Androgen; Transcription factor; Androgen deprivation therapy; Chemistry; Prostate; Endocrinology; Internal medicine; Biology; Medicine; Cancer; Gene; Hormone; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001049132,0.0002683825,0.0002373387,0.0002008319,0.0001069828,0.0002086834,0.0003471864,0.000159439,0.0007307262],"category_scores_gemma":[0.00004201214,0.000114349,0.0002311643,0.0001255057,0.0001274828,0.0001355625,0.0001333645,0.0004880292,0.0002242264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002514911,"about_ca_system_score_gemma":0.0002994961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006003933,"about_ca_topic_score_gemma":0.001445274,"domain_scores_codex":[0.9999473,0.000007003878,0.00000372069,0.00001056307,0.00001914245,0.00001225734],"domain_scores_gemma":[0.9999802,0.000002274799,0.000005581277,0.000001876764,0.000003082591,0.000006928994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001638423,0.0001598254,0.0002375007,0.0002001683,0.0000305389,0.0001173371,0.00001601045,0.000389999,0.9724755,0.000531335,0.0002744263,0.02540354],"study_design_scores_gemma":[0.000503292,0.004583385,0.005387566,0.00002589273,0.0001403391,0.001751881,0.00002006076,0.002995532,0.9455221,0.0001305103,0.03891122,0.00002815114],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9383437,0.03534032,0.01550532,0.0004289845,0.000160708,0.0004265751,0.0006877877,0.000381379,0.008725125],"genre_scores_gemma":[0.9723503,0.01424938,0.008342841,0.0001779069,0.00002858031,0.000130901,0.001092152,0.00001973933,0.003608121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007307262,"threshold_uncertainty_score":0.002444506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03430529043387877,"score_gpt":0.3280932132275991,"score_spread":0.2937879227937203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}