{"id":"W3178993652","doi":"10.1158/1538-7445.am2021-291","title":"Abstract 291: Development of optimized chemical probes targeting PI3Ka to deconvolute the role of class I PI3Ks isoforms in insulin signaling","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"","keywords":"PI3K/AKT/mTOR pathway; Gene isoform; Protein kinase B; Chemistry; Kinase; Chemical biology; Insulin receptor; Computational biology; Biochemistry; Cancer; Biology; Cancer research; Signal transduction; Insulin; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001767448,0.0005562386,0.0002083917,0.0001732307,0.0001452796,0.0002255187,0.0003860537,0.0004813947,0.002497117],"category_scores_gemma":[0.0001259794,0.0001649003,0.0002431468,0.0001590318,0.0001740843,0.0002939297,0.0001917402,0.0007020195,0.001208354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000473462,"about_ca_system_score_gemma":0.0003332229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003659607,"about_ca_topic_score_gemma":0.0004820286,"domain_scores_codex":[0.9998747,0.00001036511,0.000007482043,0.00003090556,0.00005262846,0.00002378097],"domain_scores_gemma":[0.9999382,0.000005829736,0.00002719678,0.000004520709,0.000009693511,0.00001461152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003941221,0.00003261708,0.00003995902,0.00006571644,0.000005277959,0.00003351842,0.000005803204,0.0002624094,0.9962106,0.0004136102,0.0001704934,0.002720631],"study_design_scores_gemma":[0.00002399098,0.0002208001,0.0002763535,0.000004641478,0.00000755493,0.00009233345,0.00000262446,0.001114868,0.9930699,0.00006348686,0.005116975,0.000006370728],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8716914,0.006365343,0.096648,0.000752371,0.0002336993,0.0006522626,0.001947571,0.0007321217,0.02097717],"genre_scores_gemma":[0.9274123,0.004010449,0.05321926,0.0005057015,0.00004499451,0.0003926416,0.001429921,0.0001436157,0.01284119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002497117,"threshold_uncertainty_score":0.008353651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04895795836441566,"score_gpt":0.3656477758951808,"score_spread":0.3166898175307651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}