{"id":"W3179029996","doi":"10.1038/s41467-021-24348-6","title":"Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Viral-associated cancers and disorders","field":"Medicine","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Ontario Ministry of Research and Innovation; Akademi Sains Malaysia; Health and Medical Research Fund; Medical Research Council; Hong Kong Government; Innovation and Technology Fund; Pfizer; Food and Health Bureau; Canada Research Chairs; Chinese University of Hong Kong; Universiti Malaya; National Natural Science Foundation of China; Princess Margaret Cancer Foundation; Impact Fund; Bristol-Myers Squibb","keywords":"Biology; Nasopharyngeal carcinoma; Carcinogenesis; Immune system; Innate immune system; Genome; Immunity; CDKN2A; Phenotype; Acquired immune system; Cancer research; Gene expression profiling; Gene; Genetics; Gene expression; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001025983,0.0001213741,0.0001505124,0.0003405608,0.0001465703,0.0002488763,0.00008263636,0.000141293,0.0005795087],"category_scores_gemma":[0.0001349943,0.00008130544,0.0001525199,0.000346872,0.0001057491,0.0001103554,0.0001713513,0.0001347078,0.0001994342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001423276,"about_ca_system_score_gemma":0.0001481376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000825702,"about_ca_topic_score_gemma":0.002181926,"domain_scores_codex":[0.9999273,0.000007407559,0.00000378235,0.00002204128,0.00002498867,0.00001438725],"domain_scores_gemma":[0.9999422,0.00001354374,0.00001585038,0.00000872592,0.000008257164,0.00001149813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00009347744,0.000006512891,0.01138012,0.0000467807,0.0000246008,0.0000863784,0.00004916828,0.0001196231,0.9827898,0.00004732514,0.00003967134,0.005316603],"study_design_scores_gemma":[0.000005340434,0.0001844062,0.4904307,0.00001086912,0.0001061412,0.00206255,0.0003034411,0.001662031,0.4989337,0.0002730772,0.006016506,0.00001112426],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926359,0.001691171,0.003174505,0.00003015628,0.000003605855,0.00001183316,0.001562512,0.00006333758,0.0008270659],"genre_scores_gemma":[0.9936685,0.0009014995,0.002634126,0.00002605547,0.000002164866,0.00001218336,0.001855569,0.00001453257,0.000885424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000825702,"threshold_uncertainty_score":0.001938641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01462266890073152,"score_gpt":0.2914131907331312,"score_spread":0.2767905218323996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}