{"id":"W3179029996","doi":"10.1038/s41467-021-24348-6","title":"Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Viral-associated cancers and disorders","field":"Medicine","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Ontario Ministry of Research and Innovation; Akademi Sains Malaysia; Health and Medical Research Fund; Medical Research Council; Hong Kong Government; Innovation and Technology Fund; Pfizer; Food and Health Bureau; Canada Research Chairs; Chinese University of Hong Kong; Universiti Malaya; National Natural Science Foundation of China; Princess Margaret Cancer Foundation; Impact Fund; Bristol-Myers Squibb","keywords":"Biology; Nasopharyngeal carcinoma; Carcinogenesis; Immune system; Innate immune system; Genome; Immunity; CDKN2A; Phenotype; Acquired immune system; Cancer research; Gene expression profiling; Gene; Genetics; Gene expression; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002865598,0.0001244227,0.0002836337,0.0001456074,0.0001559962,0.00002493806,0.0001804056,0.0003043076,0.00002380376],"category_scores_gemma":[0.0002292785,0.0001314817,0.00005963446,0.0002795301,0.00009307205,0.0001977575,0.0001121682,0.0007937272,0.000003507611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001721254,"about_ca_system_score_gemma":0.0002966596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004364491,"about_ca_topic_score_gemma":0.0001060901,"domain_scores_codex":[0.9989055,0.000162496,0.0004065652,0.0001901496,0.0001833089,0.0001520094],"domain_scores_gemma":[0.99862,0.0001089303,0.0001778695,0.0008148876,0.0002248862,0.00005347438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00007555575,0.0001605233,0.08709016,0.00009323803,0.00004362909,0.000003289038,0.0008299298,0.0000169269,0.9079373,0.003124967,0.0001530815,0.0004713988],"study_design_scores_gemma":[0.004011353,0.0001300419,0.8512919,0.0002417007,0.00009757889,0.00001233753,0.001949168,0.0007770181,0.137513,0.0003352705,0.003376602,0.0002640504],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9687071,0.02084635,0.00001746261,0.005768299,0.00004871361,0.000476794,0.00005307751,0.00003150943,0.004050662],"genre_scores_gemma":[0.995782,0.001014656,0.001227555,0.0004747871,0.00003096262,0.00004936076,0.001272003,0.00001985425,0.0001288885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7704244,"threshold_uncertainty_score":0.5361669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01462266890073152,"score_gpt":0.2914131907331312,"score_spread":0.2767905218323996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}