{"id":"W3179084811","doi":"10.1016/j.kint.2021.06.026","title":"Significance of HLA-DQ in kidney transplantation: time to reevaluate human leukocyte antigen–matching priorities to improve transplant outcomes? An expert review and recommendations","year":2021,"lang":"en","type":"review","venue":"Kidney International","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Vlaamse regering; National Institute for Health and Care Research; Fonds Wetenschappelijk Onderzoek; American Society of Nephrology","keywords":"Human leukocyte antigen; Medicine; Histocompatibility Testing; Transplantation; Matching (statistics); Intensive care medicine; Kidney transplantation; Histocompatibility; Immunology; Clinical significance; HLA-DQ; Graft rejection; Antigen; Internal medicine; Pathology; Biology; Genetics; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01140285,0.001051117,0.003989028,0.002627731,0.0006441569,0.002906102,0.00272497,0.003872294,0.008357715],"category_scores_gemma":[0.02847175,0.0004232353,0.002992776,0.002564486,0.001180612,0.005016987,0.001367832,0.006046522,0.00157256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003078673,"about_ca_system_score_gemma":0.009553198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009688133,"about_ca_topic_score_gemma":0.01581507,"domain_scores_codex":[0.9968814,0.001238183,0.0007847148,0.000296813,0.0006369063,0.0001621547],"domain_scores_gemma":[0.9779236,0.01390714,0.001809663,0.0002790468,0.00548216,0.0005984334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002182566,0.00007177988,0.0007939828,0.06674273,0.0008809138,0.000148747,0.0002335561,0.0003414939,0.0001257051,0.006989841,0.2287661,0.6946869],"study_design_scores_gemma":[0.0002020588,0.0001075414,0.002196871,0.2276481,0.002215303,0.0005979312,0.0005439715,0.0003363613,0.00007921698,0.01178418,0.7541959,0.00009265237],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006023997,0.9744598,0.000188382,0.02238162,0.002368694,0.00001842453,0.00004599752,0.000007740739,0.0004690593],"genre_scores_gemma":[0.001128283,0.9819856,0.0007212198,0.01302445,0.002708356,0.00005165577,0.00008413027,0.00000449567,0.0002918678],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01140285,"threshold_uncertainty_score":0.0603047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05443590775018471,"score_gpt":0.4132137962114649,"score_spread":0.3587778884612802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}