{"id":"W3179219075","doi":"10.1371/journal.ppat.1009661","title":"Respiring to infect: Emerging links between mitochondria, the electron transport chain, and fungal pathogenesis","year":2021,"lang":"en","type":"review","venue":"PLoS Pathogens","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Institute of Infection and Immunity; Canadian Institutes of Health Research; National Research Foundation of Korea; Ministry of Science, ICT and Future Planning; National Research Foundation; Canadian Institute for Advanced Research; Burroughs Wellcome Fund","keywords":"Cryptococcus neoformans; Aspergillus fumigatus; Biology; Candida albicans; Microbiology; Antifungal drug; Cryptococcosis; Virulence; Aspergillosis; Disease; Fungus; Population; Mitochondrion; Immunology; Medicine; Gene; Pathology; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007975076,0.0007499313,0.002905763,0.0002599733,0.0003333993,0.00005299741,0.0002818411,0.0008097742,0.00007396548],"category_scores_gemma":[0.0005397199,0.0005268598,0.0009752331,0.000886798,0.00009773359,0.00006206435,0.000128276,0.001542589,0.00005157197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002064181,"about_ca_system_score_gemma":0.0006629131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001550132,"about_ca_topic_score_gemma":0.00008342818,"domain_scores_codex":[0.9957978,0.0003759468,0.00107863,0.001211962,0.0006799291,0.00085573],"domain_scores_gemma":[0.9973797,0.0004564788,0.000262268,0.001217086,0.0002276968,0.0004567445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005340009,0.0001980002,0.03664151,0.01980193,0.001148239,0.0007957683,0.0005495835,5.173542e-7,0.003490053,0.0000479347,0.0002362906,0.9370368],"study_design_scores_gemma":[0.0003907312,0.0004098926,0.02521668,0.01996829,0.008706643,0.0001071622,0.0001256292,0.000002399235,0.0002570977,0.000009656294,0.9438357,0.0009700583],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0438285,0.9527597,0.0001516165,0.0002898262,0.0001389543,0.00209112,0.0002897304,0.0001085184,0.0003420291],"genre_scores_gemma":[0.004295881,0.9922378,0.0003568089,0.000306465,0.001294492,0.0002674122,0.0002937128,0.0001674336,0.0007800127],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9435995,"threshold_uncertainty_score":0.9997183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0543793410253259,"score_gpt":0.3385580104094412,"score_spread":0.2841786693841153,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}