{"id":"W3179219574","doi":"10.1158/1538-7445.am2021-954","title":"Abstract 954: AO-176, a highly differentiated clinical stage anti-CD47 antibody, is efficacious in pre-clinical models of lymphoma","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pediatric Oncology Group","funders":"","keywords":"CD47; Cancer research; Lymphoma; Immune system; Phagocytosis; Antibody; Innate immune system; Immune checkpoint; Antibody-dependent cell-mediated cytotoxicity; Immunology; Cytotoxicity; In vivo; Monoclonal antibody; Chemistry; Biology; Immunotherapy; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002573743,0.0004496334,0.000402955,0.0002712368,0.0001457939,0.0002811945,0.0003718102,0.0005588431,0.003259624],"category_scores_gemma":[0.0001451086,0.0001241524,0.0001854764,0.0001734482,0.0002316652,0.0002914454,0.0001365163,0.001272959,0.0006584658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002933692,"about_ca_system_score_gemma":0.0003669216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004241125,"about_ca_topic_score_gemma":0.000601058,"domain_scores_codex":[0.9998628,0.00002886337,0.00001005015,0.00001713255,0.0000412312,0.00003997576],"domain_scores_gemma":[0.9998749,0.00001720663,0.00002862177,0.0000122304,0.00001534888,0.00005164969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005078027,0.004210776,0.000306512,0.0001739782,0.00003343749,0.0001451491,0.00003092463,0.0002581597,0.9753942,0.0003757613,0.001026634,0.01296642],"study_design_scores_gemma":[0.001834956,0.04384891,0.004753912,0.00001764197,0.0000712636,0.0007550471,0.00003081948,0.001084998,0.9386742,0.00009266239,0.008824307,0.00001136736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894231,0.002674761,0.001634515,0.0003312349,0.0001262685,0.0003071672,0.0006129266,0.0002363505,0.004653695],"genre_scores_gemma":[0.9907125,0.001016532,0.001442433,0.000166368,0.00004045252,0.0001689656,0.00108335,0.00002042644,0.005348946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003259624,"threshold_uncertainty_score":0.01090455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1517061706802037,"score_gpt":0.4726794218566161,"score_spread":0.3209732511764124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}