{"id":"W3179257080","doi":"10.1158/1538-7445.am2021-2255","title":"Abstract 2255: The impact of primary immunodeficiency informed molecular landscape on the biology and prognosis of refractory malignancies","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Primary immunodeficiency; Biology; Transcriptome; Cancer; Immune system; Gene; Immunodeficiency; Computational biology; Gene expression; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007487622,0.0002340001,0.0004973728,0.0009387321,0.0002525402,0.001291103,0.0002845695,0.0002603894,0.007502865],"category_scores_gemma":[0.002092921,0.0001017919,0.0004949258,0.001525261,0.0002309848,0.0003635355,0.0005444306,0.0003923599,0.00118139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004040406,"about_ca_system_score_gemma":0.0005013537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009910658,"about_ca_topic_score_gemma":0.001068567,"domain_scores_codex":[0.999507,0.0001033958,0.00004070884,0.0001662115,0.0001167554,0.00006589862],"domain_scores_gemma":[0.9991671,0.0003207547,0.00020819,0.00007886058,0.0001220485,0.0001030204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002154399,0.0001104681,0.7787465,0.002407794,0.001222438,0.0007038538,0.0002718738,0.002872056,0.04074255,0.001703777,0.03052889,0.1385354],"study_design_scores_gemma":[0.00004188158,0.000218332,0.9488992,0.0003214088,0.0008665185,0.001811312,0.0002014114,0.003340961,0.006514396,0.002425486,0.03532909,0.00002987213],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.861283,0.03360509,0.006880269,0.001997591,0.0002260607,0.0000908037,0.08163029,0.0008504672,0.0134364],"genre_scores_gemma":[0.963468,0.003562926,0.003167924,0.0004996356,0.0001346959,0.0000570685,0.02746915,0.0001415971,0.001499031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007502865,"threshold_uncertainty_score":0.02509958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05223443136007342,"score_gpt":0.3876361111715848,"score_spread":0.3354016798115114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}