{"id":"W3179285598","doi":"10.3390/biomedicines9070803","title":"Ultrasound and Microbubbles for Targeted Drug Delivery to the Lung Endothelium in ARDS: Cellular Mechanisms and Therapeutic Opportunities","year":2021,"lang":"en","type":"review","venue":"Biomedicines","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University; University of Toronto; St. Michael's Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; California HIV/AIDS Research Program","keywords":"Microbubbles; ARDS; Drug delivery; Medicine; Lung; Drug; Endothelium; Ultrasound; Pharmacology; Intensive care medicine; Pathology; Internal medicine; Radiology; Nanotechnology; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002228905,0.000328641,0.0007421734,0.0002144235,0.00009679134,0.00006250205,0.0001704438,0.0001267482,0.00001799081],"category_scores_gemma":[0.00001745448,0.0002162356,0.00009208423,0.0002284161,0.00008045093,0.00002663791,0.00002748477,0.0001295775,0.000002052977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003860176,"about_ca_system_score_gemma":0.00006519328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000380914,"about_ca_topic_score_gemma":0.00005671702,"domain_scores_codex":[0.9989896,0.00004318364,0.0003387001,0.0002694241,0.00009271674,0.0002663888],"domain_scores_gemma":[0.9990295,0.0005475525,0.00004838392,0.0002449191,0.00003699693,0.00009260317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00000509658,0.0000578755,0.000009649485,0.02144989,0.0008453967,0.00001977939,0.002711382,0.000009864196,0.02167061,0.002177434,0.01170054,0.9393425],"study_design_scores_gemma":[0.0001408906,0.0000123727,0.000003570827,0.002086827,0.000411319,0.0000572636,0.0008435675,0.00004721374,0.0001368958,0.0001478967,0.9958463,0.0002658624],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004833687,0.9961773,0.00148344,0.0001855068,0.00023584,0.001039905,0.0002865007,0.00007046205,0.00003769914],"genre_scores_gemma":[0.0005642874,0.9973089,0.0006045598,0.0001643176,0.0002304556,0.0005623893,0.0002399855,0.0000733278,0.000251847],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9841458,"threshold_uncertainty_score":0.8817831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03479551177434583,"score_gpt":0.2595843010240636,"score_spread":0.2247887892497178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}