{"id":"W3179338758","doi":"10.1128/aem.00987-21","title":"Proteome, Bioinformatic, and Functional Analyses Reveal a Distinct and Conserved Metabolic Pathway for Bile Salt Degradation in the <i>Sphingomonadaceae</i>","year":2021,"lang":"en","type":"article","venue":"Applied and Environmental Microbiology","topic":"Steroid Chemistry and Biochemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Deutsche Forschungsgemeinschaft; Deutscher Akademischer Austauschdienst","keywords":"Steroid; Biochemistry; Biology; Gene; Bile acid; Metabolic pathway; Amidase; Enzyme; Chemistry; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002349066,0.0005863383,0.0004370083,0.000839924,0.0004348415,0.000701545,0.0001744179,0.0003666476,0.0007630508],"category_scores_gemma":[0.0004306425,0.0001171629,0.0006512325,0.0008879949,0.0002666687,0.0004660786,0.0004288148,0.0004396673,0.0006509031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002724636,"about_ca_system_score_gemma":0.0005648274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00130325,"about_ca_topic_score_gemma":0.001694452,"domain_scores_codex":[0.9998268,0.00001749928,0.00001667818,0.00005298723,0.00004921955,0.00003675071],"domain_scores_gemma":[0.9997676,0.0000363441,0.0000647979,0.00002577913,0.00005594458,0.00004956216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000314158,0.00004979612,0.01109894,0.0003885895,0.00005816506,0.0003938867,0.0001607092,0.0002230829,0.9731607,0.0002346271,0.0005071256,0.01341028],"study_design_scores_gemma":[0.00003886718,0.0006129236,0.5136354,0.0001821502,0.000488821,0.008053058,0.001805566,0.01132093,0.4105047,0.002854545,0.0503627,0.0001403951],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9600642,0.005468632,0.01597287,0.0008572378,0.000118356,0.0000647704,0.01293846,0.0005524491,0.003963028],"genre_scores_gemma":[0.9450343,0.003185899,0.02325993,0.0003812519,0.0000573901,0.000065445,0.02554299,0.0001343313,0.00233853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00130325,"threshold_uncertainty_score":0.002591312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01305186322392517,"score_gpt":0.2131837710974029,"score_spread":0.2001319078734777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}