{"id":"W3179338758","doi":"10.1128/aem.00987-21","title":"Proteome, Bioinformatic, and Functional Analyses Reveal a Distinct and Conserved Metabolic Pathway for Bile Salt Degradation in the <i>Sphingomonadaceae</i>","year":2021,"lang":"en","type":"article","venue":"Applied and Environmental Microbiology","topic":"Steroid Chemistry and Biochemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Deutsche Forschungsgemeinschaft; Deutscher Akademischer Austauschdienst","keywords":"Steroid; Biochemistry; Biology; Gene; Bile acid; Metabolic pathway; Amidase; Enzyme; Chemistry; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001046708,0.0001386136,0.0001402217,0.00001092779,0.0001003711,0.00002078473,0.00004574005,0.0001262627,0.000007345026],"category_scores_gemma":[0.00001255235,0.0001051247,0.00002867426,0.00003158097,0.000184013,0.00000385057,0.00009522159,0.00006715239,4.65711e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005083748,"about_ca_system_score_gemma":0.00001652497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004480449,"about_ca_topic_score_gemma":0.00001032095,"domain_scores_codex":[0.9993474,0.00002225413,0.0001692671,0.0002831533,0.00002587752,0.0001520616],"domain_scores_gemma":[0.9997434,0.00003400903,0.0000596501,0.0001243708,0.000004035568,0.00003453531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006145546,0.00003902218,0.002626022,0.00004296692,0.00002994149,0.000001027162,0.0000339006,7.727417e-7,0.9962329,0.00001428514,0.0001656422,0.0007520318],"study_design_scores_gemma":[0.0008511704,0.00003954472,0.007254593,0.000004820976,0.00002595145,0.0002573058,0.0005070212,0.00001050463,0.9819796,0.00005504741,0.008872589,0.0001418522],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971362,0.002068104,0.0001441998,0.0001461075,0.00001420786,0.0002051805,0.0001969722,0.00000294157,0.00008609591],"genre_scores_gemma":[0.9964204,0.0003072891,0.0003625365,0.0004826741,0.00005204291,0.00009225322,0.002162022,0.000006650603,0.0001141528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01425333,"threshold_uncertainty_score":0.428686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01305186322392517,"score_gpt":0.2131837710974029,"score_spread":0.2001319078734777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}