{"id":"W3179474508","doi":"10.1016/j.vaccine.2021.07.002","title":"Evaluation of the stability of a spray-dried tuberculosis vaccine candidate designed for dry powder respiratory delivery","year":2021,"lang":"en","type":"article","venue":"Vaccine","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Dry-powder inhaler; Trehalose; Excipient; Spray drying; Adjuvant; Particle size; Materials science; Aerosolization; Chemistry; Medicine; Chromatography; Immunology; Inhaler; Organic chemistry; Anesthesia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002222457,0.0001721981,0.0004731234,0.0001238594,0.00009847718,0.000006627928,0.0001108549,0.0001399975,0.0009868126],"category_scores_gemma":[0.001246981,0.0001231309,0.0002666633,0.0005297876,0.00001971712,0.0001096462,0.00006923223,0.0001348726,0.000004442505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001619617,"about_ca_system_score_gemma":0.001080325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003586244,"about_ca_topic_score_gemma":0.0002118486,"domain_scores_codex":[0.9974953,0.0004943755,0.0007228673,0.0003241793,0.000758774,0.0002045287],"domain_scores_gemma":[0.9953335,0.0002071901,0.0003101679,0.0007487155,0.003313282,0.00008717866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009945238,0.000476613,0.06696261,0.0004711086,0.0003487236,0.000003422979,0.0003460601,0.0001250326,0.9217777,0.00008126492,0.001769722,0.006643225],"study_design_scores_gemma":[0.007206398,0.0002260475,0.09879404,0.0001440819,0.001040144,0.000004733488,0.0002790923,0.001172124,0.889221,0.00005561245,0.001725971,0.0001307361],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956432,0.00156793,0.0001533671,0.0007085096,0.0002375919,0.001183577,0.00007005795,0.00002273886,0.0004130057],"genre_scores_gemma":[0.9984941,0.00002568879,0.000277758,0.0008387311,0.0001213858,0.00005568212,0.00003412315,0.00002609604,0.0001264288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03255668,"threshold_uncertainty_score":0.9999264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0436707920642332,"score_gpt":0.3025974877324346,"score_spread":0.2589266956682014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}