{"id":"W3179482875","doi":"10.1038/s42003-021-02397-3","title":"Three-dimensional CRISPR screening reveals epigenetic interaction with anti-angiogenic therapy","year":2021,"lang":"en","type":"article","venue":"Communications Biology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Peter MacCallum Cancer Centre; University of Melbourne; Medical Research Council; National Health and Medical Research Council; State Government of Victoria; Australian Government","keywords":"Epigenetics; Angiogenesis; Biology; CRISPR; Cancer research; Reprogramming; Cas9; Genetics; Cell; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001815069,0.0002375827,0.0002831924,0.000219165,0.0001132375,0.0003877264,0.0002551212,0.0003071056,0.001241926],"category_scores_gemma":[0.0001808714,0.0001355526,0.0002650089,0.0001237292,0.0001793678,0.0000893053,0.0002536335,0.0003629757,0.000288955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003183481,"about_ca_system_score_gemma":0.0002411052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007873647,"about_ca_topic_score_gemma":0.001592474,"domain_scores_codex":[0.9997959,0.00002230224,0.00001630586,0.00004686895,0.00008146207,0.00003726011],"domain_scores_gemma":[0.9998788,0.0000336173,0.00003818057,0.0000166793,0.0000136199,0.00001915946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003702401,0.00001729229,0.0001539008,0.00001685091,0.00000550075,0.00004485159,0.000005325605,0.000240045,0.9977292,0.000114042,0.00004781471,0.001588118],"study_design_scores_gemma":[0.00000614498,0.0001126837,0.00231046,0.000002678883,0.00001654723,0.0001295924,0.000008987115,0.002601497,0.9927073,0.00006155969,0.002035642,0.000006795596],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9683574,0.0007913143,0.0245991,0.000195624,0.00004587844,0.00007535951,0.001248222,0.0007226359,0.003964527],"genre_scores_gemma":[0.9847597,0.0004034273,0.01065049,0.00009515315,0.000004220075,0.00004295479,0.0007632155,0.00006044727,0.003220346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001241926,"threshold_uncertainty_score":0.004154623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04344702161719369,"score_gpt":0.3164502859979406,"score_spread":0.2730032643807468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}