{"id":"W3179498946","doi":"10.1158/1538-7445.am2021-ct191","title":"Abstract CT191: A window-of-opportunity study with atezolizumab and the oncolytic virus pelareorep in early breast cancer (AWARE-1)","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"","keywords":"Atezolizumab; Medicine; Oncology; Cohort; Internal medicine; Breast cancer; Letrozole; Trastuzumab; Clinical endpoint; Cancer; Oncolytic virus; Immunotherapy; Pembrolizumab; Clinical trial; Tamoxifen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001479784,0.000876359,0.001269137,0.0003688139,0.0004142652,0.0007080714,0.0007157453,0.0009209435,0.002212577],"category_scores_gemma":[0.0006894493,0.0004070257,0.0008763941,0.0003393969,0.0006902359,0.0007373766,0.0003903161,0.002391158,0.0004154078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007426858,"about_ca_system_score_gemma":0.001219343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001104085,"about_ca_topic_score_gemma":0.001641423,"domain_scores_codex":[0.9994604,0.0002258588,0.00003545552,0.00009209039,0.00007049444,0.000115645],"domain_scores_gemma":[0.9991968,0.0001693953,0.0001327719,0.0001067996,0.00004715601,0.0003470068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5759212,0.2039252,0.01578209,0.0004090493,0.000746591,0.0005755143,0.0003438712,0.0008973902,0.1550024,0.0002297214,0.001114975,0.04505192],"study_design_scores_gemma":[0.04535585,0.9248772,0.01587746,0.0000103179,0.0002797925,0.0002850803,0.00007251741,0.000281723,0.01189101,0.00006594976,0.0009835463,0.00001939254],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983262,0.0003977299,0.0001383091,0.0000706362,0.00003016914,0.0004419502,0.0002857993,0.00001071069,0.0002983477],"genre_scores_gemma":[0.994975,0.0007028199,0.0005560776,0.0002474645,0.0001545424,0.0008102742,0.000970461,0.000009466842,0.001573899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002212577,"threshold_uncertainty_score":0.007825971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0522293949198893,"score_gpt":0.3907557235460781,"score_spread":0.3385263286261888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}