{"id":"W3179524201","doi":"10.1007/s00262-021-02975-8","title":"Stem cells-derived natural killer cells for cancer immunotherapy: current protocols, feasibility, and benefits of ex vivo generated natural killer cells in treatment of advanced solid tumors","year":2021,"lang":"en","type":"review","venue":"Cancer Immunology Immunotherapy","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Immunotherapy; Cancer research; Lymphokine-activated killer cell; Cancer immunotherapy; Ex vivo; Tumor microenvironment; Natural killer cell; Cell therapy; Biology; Immunology; Interleukin 21; Interleukin 12; Cytotoxic T cell; Stem cell; T cell; In vivo; Immune system; In vitro; Cell biology; Tumor cells; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009108416,0.001008416,0.001285715,0.001593009,0.0001830045,0.001061502,0.0009379301,0.001013917,0.002183614],"category_scores_gemma":[0.0007021737,0.0002574432,0.0003990268,0.001563032,0.0005124019,0.001315535,0.0006478457,0.002427931,0.001833885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005270608,"about_ca_system_score_gemma":0.000785627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006656478,"about_ca_topic_score_gemma":0.001389098,"domain_scores_codex":[0.9998017,0.00003225446,0.00002275266,0.00003268057,0.0000895402,0.00002108998],"domain_scores_gemma":[0.9996414,0.0001893364,0.00004024347,0.00001009818,0.00008622905,0.00003263102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001296693,0.00009681485,0.0001180599,0.009271307,0.00005505066,0.0001074992,0.00003748694,0.0004153031,0.004295463,0.003875127,0.01927458,0.9623237],"study_design_scores_gemma":[0.00004595762,0.0001832777,0.000601389,0.002460724,0.00009357784,0.000866819,0.00003938139,0.0001603429,0.001760695,0.002309596,0.991454,0.00002425629],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009528109,0.9989309,0.0001965171,0.0001428682,0.0001822189,0.00000381778,0.00001278463,0.000004962344,0.000430755],"genre_scores_gemma":[0.0004961155,0.9984515,0.0002566933,0.0001418868,0.0001437985,0.000006491011,0.00002934655,0.000001594211,0.0004725713],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002183614,"threshold_uncertainty_score":0.007304907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05333067913254801,"score_gpt":0.3528599958987678,"score_spread":0.2995293167662197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}