{"id":"W3179596625","doi":"10.1016/j.hroo.2021.06.008","title":"Quantifying arrhythmic long QT effects of hydroxychloroquine and azithromycin with whole-heart optical mapping and simulations","year":2021,"lang":"en","type":"article","venue":"Heart Rhythm O2","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Prince Edward Island","funders":"Natural Resources, Energy and Science Authority of Sri Lanka; National Institutes of Health; National Science Foundation","keywords":"QT interval; Medicine; Hydroxychloroquine; Torsades de pointes; Repolarization; Azithromycin; Optical mapping; Pharmacology; Long QT syndrome; Cardiology; Reentry; Cardiac arrhythmia; Afterdepolarization; Internal medicine; Coronavirus disease 2019 (COVID-19); Electrophysiology; Chemistry; Atrial fibrillation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001921051,0.0003469629,0.0002590841,0.0002870281,0.0001854,0.0004231324,0.0004817499,0.001092807,0.00128163],"category_scores_gemma":[0.0009606988,0.0001669714,0.000537606,0.0001732232,0.0003583745,0.0003404615,0.0003002987,0.0003710745,0.0001215974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004573249,"about_ca_system_score_gemma":0.000457401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006564243,"about_ca_topic_score_gemma":0.002936648,"domain_scores_codex":[0.9999365,0.00001560395,0.000003819627,0.00001339934,0.00001868769,0.00001195274],"domain_scores_gemma":[0.9995889,0.0002750808,0.00005810798,0.00002305195,0.00003537365,0.00001940735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00002910584,0.00003097347,0.00127905,0.00003727863,0.00001308384,0.00006181454,0.00002802658,0.9907032,0.004564197,0.001214494,0.0001516476,0.001887186],"study_design_scores_gemma":[0.000006408626,0.00001418043,0.000308156,0.000003040451,0.000003825853,0.00001590073,0.00000852671,0.9985202,0.000656325,0.0002854133,0.0001753422,0.000002807555],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8844751,0.000597104,0.0965533,0.0006235305,0.00007336401,0.00008295333,0.0006372201,0.0003515399,0.01660586],"genre_scores_gemma":[0.9886185,0.0002023682,0.00964417,0.00006996714,0.00001030435,0.00005481429,0.0001554808,0.00002854463,0.001215882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006564243,"threshold_uncertainty_score":0.01305205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01413429761905379,"score_gpt":0.2684176174359115,"score_spread":0.2542833198168577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}