{"id":"W3179639426","doi":"10.1093/cercor/bhab224","title":"The Orphan GPCR Receptor, GPR88, Interacts with Nuclear Protein Partners in the Cerebral Cortex","year":2021,"lang":"en","type":"article","venue":"Cerebral Cortex","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"Centre National de la Recherche Scientifique","keywords":"Cell biology; Nuclear localization sequence; Subcellular localization; Proximity ligation assay; Nuclear transport; Nucleus accumbens; Nuclear membrane; G protein-coupled receptor; Orphan receptor; Biology; Medium spiny neuron; Chemistry; Neuroscience; Cell nucleus; Receptor; Nucleus; Cytoplasm; Biochemistry; Gene; Central nervous system; Transcription factor; Basal ganglia; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001002731,0.0002605633,0.0002713364,0.0002565137,0.0002191079,0.0002464562,0.0001815031,0.0001673649,0.001252717],"category_scores_gemma":[0.0001566066,0.0001693247,0.0002371518,0.0001654389,0.0001851904,0.0001727316,0.0004534512,0.0002661917,0.0005036648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003245732,"about_ca_system_score_gemma":0.0001991343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001798271,"about_ca_topic_score_gemma":0.002733902,"domain_scores_codex":[0.9998608,0.00001891425,0.000005416739,0.0000381336,0.00003991895,0.0000368393],"domain_scores_gemma":[0.9999372,0.000006465144,0.00002304573,0.000007206566,0.000007496681,0.00001863757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008430039,0.000006146606,0.0008709744,0.00003425537,0.00001031574,0.0002218526,0.00002152445,0.00003877265,0.9975355,0.0001134999,0.000067866,0.0009949515],"study_design_scores_gemma":[0.00004250069,0.0001677316,0.1823661,0.00004025542,0.00008392687,0.004300741,0.000291889,0.002125536,0.8033496,0.0003669038,0.006840189,0.00002470087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930803,0.002127577,0.002597379,0.0002167903,0.00001407088,0.000007576496,0.0002602628,0.00006227102,0.00163369],"genre_scores_gemma":[0.994429,0.00103054,0.001464717,0.00007605668,0.00000765576,0.00001709094,0.0005434171,0.00001786068,0.002413538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001798271,"threshold_uncertainty_score":0.004190743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01010943751521767,"score_gpt":0.2426600732236767,"score_spread":0.232550635708459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}