{"id":"W3179639426","doi":"10.1093/cercor/bhab224","title":"The Orphan GPCR Receptor, GPR88, Interacts with Nuclear Protein Partners in the Cerebral Cortex","year":2021,"lang":"en","type":"article","venue":"Cerebral Cortex","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"Centre National de la Recherche Scientifique","keywords":"Cell biology; Nuclear localization sequence; Subcellular localization; Proximity ligation assay; Nuclear transport; Nucleus accumbens; Nuclear membrane; G protein-coupled receptor; Orphan receptor; Biology; Medium spiny neuron; Chemistry; Neuroscience; Cell nucleus; Receptor; Nucleus; Cytoplasm; Biochemistry; Gene; Central nervous system; Transcription factor; Basal ganglia; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003558784,0.0002616776,0.0002025444,0.00002600439,0.0003048142,0.0002110032,0.0004887333,0.000157113,0.0004921456],"category_scores_gemma":[0.00009289099,0.0001543882,0.0001257122,0.0002277199,0.0001283509,0.00001463225,0.0001531599,0.0003239097,0.00006209027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002857412,"about_ca_system_score_gemma":0.000160735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004466118,"about_ca_topic_score_gemma":0.0004185393,"domain_scores_codex":[0.9981255,0.0002582084,0.0003105344,0.0005240228,0.0002879645,0.0004937803],"domain_scores_gemma":[0.9989899,0.00003074589,0.0001349985,0.0006189085,0.0001224956,0.0001029866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003097111,0.0001189595,0.0008567979,0.00001953534,0.00009124791,0.00004704545,0.0004972366,0.00001320789,0.9840072,0.003855893,0.005537025,0.004646169],"study_design_scores_gemma":[0.002672438,0.001641087,0.007880425,0.0002250158,0.00006087538,0.0002210536,0.008084033,0.0003484256,0.6254838,0.0008282142,0.3514883,0.001066366],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946509,0.0003956891,0.0001137774,0.0009324249,0.0002781132,0.0004215811,0.000009231888,0.00002031272,0.00317798],"genre_scores_gemma":[0.995785,0.00006214348,0.0004665794,0.0009760964,0.0002849869,0.0000552442,0.0001218324,0.00005019796,0.002197917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3585234,"threshold_uncertainty_score":0.629577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01010943751521767,"score_gpt":0.2426600732236767,"score_spread":0.232550635708459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}