{"id":"W3179667220","doi":"10.1038/s41698-021-00178-z","title":"TCERG1L allelic variation is associated with cisplatin-induced hearing loss in childhood cancer, a PanCareLIFE study","year":2021,"lang":"en","type":"article","venue":"npj Precision Oncology","topic":"Hearing, Cochlea, Tinnitus, Genetics","field":"Neuroscience","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia; University of Alberta","funders":"Canadian Institutes of Health Research; Medizinische Universität Graz; Hospital for Sick Children; Universität Ulm; Universitair Medisch Centrum Groningen; IWK Health Centre; University of Alberta; Amsterdam University Medical Centers; Erasmus Medisch Centrum; Children's Hospital Foundation; Universitätsmedizin der Johannes Gutenberg-Universität Mainz; Karl-Franzens-Universität Graz; Stollery Children’s Hospital Foundation; Canada Research Chairs; Children's Health Research Institute; Westfälische Wilhelms-Universität Münster; Universität zu Lübeck; Women and Children's Health Research Institute; Universiteit van Amsterdam; BC Children's Hospital; University of Bern; European Commission; London Health Sciences Centre","keywords":"Ototoxicity; Cisplatin; Hearing loss; Genome-wide association study; Allele; Cancer; Oncology; Genetic variation; Phenotype; Cohort; Biology; Genetic predisposition; Toxicity; Genetics; Medicine; Cancer research; Internal medicine; Gene; Single-nucleotide polymorphism; Genotype; Chemotherapy; Audiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003374467,0.0002906345,0.0002104167,0.0003371533,0.0003601242,0.0004612603,0.0002284712,0.0002210384,0.001541399],"category_scores_gemma":[0.0009198958,0.0001880631,0.0003554195,0.0005817642,0.0002520298,0.0001253303,0.0002790715,0.0003056151,0.0001361886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002319497,"about_ca_system_score_gemma":0.000204832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008387498,"about_ca_topic_score_gemma":0.0108128,"domain_scores_codex":[0.9997318,0.00005479352,0.00002496054,0.0001091092,0.00005284252,0.00002651302],"domain_scores_gemma":[0.9995793,0.00008269394,0.0001730673,0.00004714918,0.00005043043,0.00006745107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005106103,0.00002815832,0.9902283,0.00002585592,0.0002641008,0.0006330495,0.0001678213,0.00008831335,0.005117037,0.00005568599,0.0002539949,0.002627063],"study_design_scores_gemma":[0.00002500252,0.0001156189,0.9976578,0.00000897112,0.0001766389,0.0009327671,0.00009618529,0.0001591463,0.0004146189,0.00002094249,0.0003884556,0.000003781122],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990287,0.0001723633,0.0001403317,0.00003016231,0.000003003817,0.000006967498,0.0003587642,0.000002822288,0.0002568534],"genre_scores_gemma":[0.9993743,0.0001309098,0.0001246995,0.00001890057,0.000004458981,0.00000551955,0.0002132966,0.000003586539,0.0001244232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008387498,"threshold_uncertainty_score":0.01667738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07374728584158811,"score_gpt":0.3567143088590177,"score_spread":0.2829670230174295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}