{"id":"W3179667220","doi":"10.1038/s41698-021-00178-z","title":"TCERG1L allelic variation is associated with cisplatin-induced hearing loss in childhood cancer, a PanCareLIFE study","year":2021,"lang":"en","type":"article","venue":"npj Precision Oncology","topic":"Hearing, Cochlea, Tinnitus, Genetics","field":"Neuroscience","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia; University of Alberta","funders":"Canadian Institutes of Health Research; Medizinische Universität Graz; Hospital for Sick Children; Universität Ulm; Universitair Medisch Centrum Groningen; IWK Health Centre; University of Alberta; Amsterdam University Medical Centers; Erasmus Medisch Centrum; Children's Hospital Foundation; Universitätsmedizin der Johannes Gutenberg-Universität Mainz; Karl-Franzens-Universität Graz; Stollery Children’s Hospital Foundation; Canada Research Chairs; Children's Health Research Institute; Westfälische Wilhelms-Universität Münster; Universität zu Lübeck; Women and Children's Health Research Institute; Universiteit van Amsterdam; BC Children's Hospital; University of Bern; European Commission; London Health Sciences Centre","keywords":"Ototoxicity; Cisplatin; Hearing loss; Genome-wide association study; Allele; Cancer; Oncology; Genetic variation; Phenotype; Cohort; Biology; Genetic predisposition; Toxicity; Genetics; Medicine; Cancer research; Internal medicine; Gene; Single-nucleotide polymorphism; Genotype; Chemotherapy; Audiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008893011,0.0003102022,0.0006414964,0.0002619479,0.0002339176,0.00008970407,0.0004088138,0.000372936,0.0003690415],"category_scores_gemma":[0.004667502,0.0003042245,0.00006813526,0.001419664,0.0000513492,0.0001691071,0.0004256589,0.0007734804,0.00007703272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008191764,"about_ca_system_score_gemma":0.001308078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005668065,"about_ca_topic_score_gemma":0.004235102,"domain_scores_codex":[0.9953387,0.001215033,0.0007701169,0.001171429,0.0008269765,0.0006777045],"domain_scores_gemma":[0.9972006,0.001277371,0.0003651865,0.0006608448,0.0003063877,0.0001896218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007801056,0.01069738,0.3338495,0.00003475413,0.0001915808,0.002836538,0.05597509,0.00591176,0.4478045,0.0001924086,0.001056604,0.1406697],"study_design_scores_gemma":[0.006407338,0.001923423,0.944545,0.0001686488,0.00005839275,0.00009881988,0.0005741487,0.002542267,0.04091859,0.0003088975,0.001949639,0.0005048781],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953712,0.00007393777,0.0001875771,0.001003042,0.0006490789,0.0008920874,0.00001487928,0.0001133334,0.001694818],"genre_scores_gemma":[0.9965212,0.0001409982,0.0005198682,0.002101697,0.0001291618,0.0001387604,0.000005826762,0.00006172506,0.0003807313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6106954,"threshold_uncertainty_score":0.999941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07374728584158811,"score_gpt":0.3567143088590177,"score_spread":0.2829670230174295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}