{"id":"W3179670484","doi":"10.1016/j.esmoop.2021.100211","title":"Intratumor morphologic and transcriptomic heterogeneity in V600EBRAF-mutated metastatic colorectal adenocarcinomas","year":2021,"lang":"en","type":"article","venue":"ESMO Open","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Pharmaceuticals; Seventh Framework Programme; Genentech; National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology; Servier; Regione del Veneto; Astellas Pharma; European Commission; Cancer Research UK; National Institute for Health and Care Research; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; EMD Serono; Novartis; Royal Marsden NHS Foundation Trust; NIHR Imperial Biomedical Research Centre; Amgen; Pfizer; Imperial College London; Institute of Cancer Research; Bayer; Roche; Astellas Pharma US","keywords":"KRAS; Microsatellite instability; Colorectal cancer; Neuroblastoma RAS viral oncogene homolog; Tumour heterogeneity; Genetic heterogeneity; Biology; Phenotype; Transcriptome; Cancer research; Adenocarcinoma; Grading (engineering); Pathology; Gene expression profiling; Immunohistochemistry; Medicine; Gene; Cancer; Gene expression; Genetics; Microsatellite; Allele","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002659705,0.0001343051,0.0001323888,0.001011474,0.0001609715,0.0002468447,0.0001232416,0.0001855618,0.0007130994],"category_scores_gemma":[0.0006225104,0.0001048887,0.00009311042,0.0003160899,0.0002337718,0.0001634868,0.0002314332,0.0001024314,0.0001373059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001602237,"about_ca_system_score_gemma":0.00007088955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003033538,"about_ca_topic_score_gemma":0.0007099735,"domain_scores_codex":[0.9998097,0.00003283686,0.00002999488,0.00004777971,0.00004509151,0.00003458919],"domain_scores_gemma":[0.9996444,0.0001000476,0.0001269611,0.00002710695,0.00004559357,0.00005582694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008383679,0.00005241302,0.7466477,0.00009964529,0.00004856897,0.009228422,0.0003617426,0.0002123359,0.2330182,0.00008223767,0.00007753126,0.00933286],"study_design_scores_gemma":[0.00001399012,0.0003671332,0.9491003,0.000009972466,0.00004616783,0.03134561,0.0005242146,0.0008213875,0.01698253,0.0001191781,0.0006623453,0.00000718705],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995035,0.0001570995,0.0001673776,0.000004099886,9.1075e-7,0.000006522492,0.0000295494,0.000002783307,0.00012813],"genre_scores_gemma":[0.999676,0.00004672446,0.0001749194,0.000003184853,0.000002450994,0.000004488781,0.00004893553,0.00000128642,0.00004204534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001011474,"threshold_uncertainty_score":0.002385616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04380060235115114,"score_gpt":0.3274066343797803,"score_spread":0.2836060320286292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}