{"id":"W3179679020","doi":"10.3390/cancers13143406","title":"The Genetic Analyses of French Canadians of Quebec Facilitate the Characterization of New Cancer Predisposing Genes Implicated in Hereditary Breast and/or Ovarian Cancer Syndrome Families","year":2021,"lang":"en","type":"review","venue":"Cancers","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"PALB2; Breast cancer; Genetics; Ovarian cancer; Population; Cancer; Biology; Gene; Medicine; Mutation; Germline mutation; Environmental health","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007029223,0.0004513696,0.0004743946,0.002397755,0.001361055,0.0007851925,0.0004686454,0.0004768764,0.002401705],"category_scores_gemma":[0.001025602,0.00009372918,0.0006664609,0.002579143,0.0006045679,0.0001852312,0.0002653117,0.0005131258,0.0002085404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01097264,"about_ca_system_score_gemma":0.008825635,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9085509,"about_ca_topic_score_gemma":0.9538161,"domain_scores_codex":[0.9995568,0.00005285761,0.00002856887,0.00009667619,0.0001762103,0.0000887931],"domain_scores_gemma":[0.9993074,0.0001175127,0.00007141774,0.00001477646,0.0004336051,0.00005524775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004378195,0.00005162034,0.2268097,0.005007411,0.001200112,0.009114522,0.003191519,0.00194901,0.02785727,0.01106388,0.04562694,0.6676903],"study_design_scores_gemma":[0.0000334051,0.00008642844,0.4696429,0.001671091,0.0008507295,0.009320368,0.00141441,0.0004564096,0.003186269,0.001136208,0.5121024,0.0000993892],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1701558,0.7715961,0.004410238,0.006371194,0.0007265201,0.0001300335,0.008104078,0.00014688,0.03835908],"genre_scores_gemma":[0.5248045,0.4322909,0.01265476,0.003623949,0.0002992295,0.0001013321,0.007063269,0.00005444969,0.01910762],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.09144908,"threshold_uncertainty_score":0.1839752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03883085551272799,"score_gpt":0.3231279605180336,"score_spread":0.2842971050053056,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}