{"id":"W3179690541","doi":"10.1093/biomethods/bpab004","title":"Optimization and biological validation of an <i>in vitro</i> assay using the transfected Dm28c/pLacZ <i>Trypanosoma cruzi</i> strain","year":2021,"lang":"en","type":"article","venue":"Biology Methods and Protocols","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Trypanosoma cruzi; Nifurtimox; Amastigote; Benznidazole; Bioassay; In vitro; Strain (injury); In vitro toxicology; Chagas disease; Molecular biology; Biology; Chemistry; Microbiology; Biochemistry; Virology; Parasite hosting; Leishmania","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002045251,0.001617777,0.001754126,0.0006085018,0.0005083595,0.0009409856,0.0009709825,0.000914836,0.001392047],"category_scores_gemma":[0.001322127,0.0005338345,0.000941847,0.0009269358,0.0006193677,0.0003876065,0.0005345927,0.001333196,0.002077569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008152297,"about_ca_system_score_gemma":0.0005193561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002973969,"about_ca_topic_score_gemma":0.002883415,"domain_scores_codex":[0.9975058,0.0007888997,0.0003091863,0.0003320433,0.0008483902,0.0002156275],"domain_scores_gemma":[0.9987748,0.000368561,0.0002101121,0.000191838,0.0003676437,0.00008699778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004080905,0.00005422514,0.00006581566,0.00007536194,0.000005809271,0.00002299392,0.00002363092,0.00007162013,0.9989342,0.00003523006,0.00005997449,0.0006102321],"study_design_scores_gemma":[0.000008396469,0.0003399985,0.0007132994,0.000009171374,0.0000297503,0.00008195735,0.00001975479,0.0006527683,0.9964576,0.00001355769,0.001661195,0.00001249444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.8696532,0.003553288,0.1097281,0.0006336041,0.0004280284,0.001475233,0.006386306,0.001821827,0.006320263],"genre_scores_gemma":[0.7457987,0.004245386,0.2115654,0.0003017996,0.0001333822,0.001935994,0.02189548,0.0009483261,0.01317553],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.002973969,"threshold_uncertainty_score":0.0108164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1352993334674543,"score_gpt":0.483322546083806,"score_spread":0.3480232126163517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}