{"id":"W3179720171","doi":"10.1089/dia.2021.0108","title":"Immunogenicity of the novel glucagon analog dasiglucagon: Results of a dedicated immunogenicity trial in type 1 diabetes","year":2021,"lang":"en","type":"article","venue":"Diabetes Technology & Therapeutics","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"LMC Diabetes & Endocrinology (Canada)","funders":"","keywords":"Immunogenicity; Medicine; Hypoglycemia; Clinical endpoint; Type 1 diabetes; Glucagon; Diabetes mellitus; Subcutaneous injection; Type 2 diabetes; Internal medicine; Randomized controlled trial; Incidence (geometry); Clinical trial; Insulin; Antibody; Immunology; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006837859,0.0002526189,0.0008160397,0.0001766997,0.00009805972,0.000008028717,0.0004708075,0.0004510285,0.00003406385],"category_scores_gemma":[0.0007026263,0.0001852304,0.0002342487,0.002225726,0.0007912495,0.00005980827,0.0004020523,0.0008154333,0.000003704754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007901494,"about_ca_system_score_gemma":0.0002594453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002854653,"about_ca_topic_score_gemma":0.0000336866,"domain_scores_codex":[0.9977188,0.0001626011,0.0009001451,0.0003758012,0.0003274475,0.0005151934],"domain_scores_gemma":[0.9975629,0.0005581818,0.0004988783,0.0008941613,0.0004381221,0.00004779673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007571847,0.001643651,0.07260193,0.0001044065,0.002008995,0.000004775326,0.0001767515,0.000003473852,0.9004043,0.0002310431,0.00002816399,0.01522062],"study_design_scores_gemma":[0.02670908,0.0009461003,0.02896157,0.0001784133,0.001055638,0.000004144789,0.0002517183,0.0003188646,0.9290118,0.0005238412,0.01184565,0.000193218],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9726942,0.01907775,0.000005126151,0.006874212,0.0004048744,0.0005254991,0.00006777734,0.00006170898,0.0002888095],"genre_scores_gemma":[0.9959621,0.002529684,0.000306713,0.001055355,0.00004204486,0.00002277751,0.00002462905,0.00002473548,0.00003194518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04364036,"threshold_uncertainty_score":0.7553477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05339899138269436,"score_gpt":0.3356627159685671,"score_spread":0.2822637245858727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}