{"id":"W3179769212","doi":"10.1002/jlb.2a1220-824r","title":"miR-181c regulates MCL1 and cell survival in GATA2 deficient cells","year":2021,"lang":"en","type":"article","venue":"Journal of Leukocyte Biology","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; NHLBI Division of Intramural Research; NIH Clinical Center; National Institutes of Health","keywords":"MCL1; Biology; microRNA; GATA2; Gene knockdown; Cancer research; Myeloid; Transfection; Haematopoiesis; Myeloid leukemia; Molecular biology; Cell culture; Downregulation and upregulation; Stem cell; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001072261,0.0001632687,0.0001907304,0.0002180524,0.0001675032,0.0003427661,0.0001157366,0.0001944275,0.001049719],"category_scores_gemma":[0.0001599255,0.0001032363,0.000185625,0.0001261997,0.0001305921,0.0001000589,0.0002049055,0.0003002927,0.0005227328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002307473,"about_ca_system_score_gemma":0.0001277081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002563755,"about_ca_topic_score_gemma":0.000320716,"domain_scores_codex":[0.9998481,0.00001981381,0.00001496511,0.00003800507,0.00004435673,0.00003464384],"domain_scores_gemma":[0.9999156,0.00001237341,0.00002780252,0.000008056362,0.00001413026,0.00002205746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001476053,0.00001845506,0.000779947,0.00001724943,0.000003815465,0.00005014729,0.00001774514,0.00003684844,0.9978139,0.00004412668,0.00005489633,0.001015175],"study_design_scores_gemma":[0.00003677632,0.0004176575,0.02650668,0.000009461185,0.00002628087,0.0007454859,0.00008841705,0.001949453,0.9644597,0.00008069981,0.005670898,0.000008415852],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949976,0.001495244,0.001611008,0.00007021937,0.0000229262,0.00001941625,0.0004503668,0.0000971813,0.00123602],"genre_scores_gemma":[0.9971617,0.0002984274,0.0007321265,0.00005361562,0.000005419641,0.00002596136,0.000488072,0.00001437753,0.001220174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001049719,"threshold_uncertainty_score":0.003511667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00975076456530657,"score_gpt":0.243454117716772,"score_spread":0.2337033531514655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}