{"id":"W3179777934","doi":"","title":"Subretinal gene replacement rescues retinal phenotype in BBS10 mouse","year":2021,"lang":"en","type":"article","venue":"","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Ophthalmology; Retinal; Retinal degeneration; Erg; Bardet–Biedl syndrome; Electroretinography; Toxicity; Biology; Cilium; Medicine; Molecular biology; Phenotype; Andrology; Gene; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003171524,0.0008155502,0.0004302547,0.0007330722,0.0002061239,0.000303803,0.0003365871,0.0007591036,0.003200569],"category_scores_gemma":[0.0001832722,0.0002756686,0.0004002074,0.0001832711,0.000409223,0.000347527,0.0002523606,0.0007655381,0.001188317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004172597,"about_ca_system_score_gemma":0.0002868614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001121494,"about_ca_topic_score_gemma":0.001867482,"domain_scores_codex":[0.9995794,0.00004247328,0.00006465374,0.00007929819,0.0001558156,0.00007825073],"domain_scores_gemma":[0.9995887,0.0000434768,0.0001619936,0.00004148775,0.00003960715,0.0001248396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008382236,0.00004216469,0.0001377103,0.00003256073,0.000003593246,0.0001077461,0.00001381073,0.00002318007,0.9988016,0.00003528735,0.00004244829,0.0006760939],"study_design_scores_gemma":[0.00005590438,0.00122818,0.006147626,0.00002889222,0.0000283045,0.001259815,0.00006950476,0.0006919332,0.9874212,0.00005113213,0.003007849,0.000009614556],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906676,0.001347039,0.003747475,0.0002267554,0.00008605926,0.00009150736,0.001257148,0.000401197,0.00217525],"genre_scores_gemma":[0.9759766,0.001649585,0.005488447,0.000148185,0.00002761037,0.0001580284,0.001816737,0.0001939407,0.01454089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003200569,"threshold_uncertainty_score":0.01070696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007953282641921014,"score_gpt":0.2364089222889046,"score_spread":0.2284556396469835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}