{"id":"W3179777934","doi":"","title":"Subretinal gene replacement rescues retinal phenotype in BBS10 mouse","year":2021,"lang":"en","type":"article","venue":"","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Ophthalmology; Retinal; Retinal degeneration; Erg; Bardet–Biedl syndrome; Electroretinography; Toxicity; Biology; Cilium; Medicine; Molecular biology; Phenotype; Andrology; Gene; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002056593,0.0001360503,0.000117912,0.00003579916,0.00004372269,0.00002738105,0.0001158849,0.000094729,0.0003553802],"category_scores_gemma":[0.0001044669,0.000132002,0.00005556272,0.0001246128,0.00003843941,0.000002841852,0.0001387029,0.00007701097,0.00003933683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001739964,"about_ca_system_score_gemma":0.0001461844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003313254,"about_ca_topic_score_gemma":0.0002152016,"domain_scores_codex":[0.9988864,0.00006324687,0.000231667,0.0004014164,0.0001536137,0.0002636499],"domain_scores_gemma":[0.9995166,0.000006187118,0.00003729045,0.0002869734,0.00008893864,0.00006399307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000517159,0.0001557904,0.09720844,0.00002400972,0.00003189814,0.00004571274,0.00006918876,0.00001912098,0.8898491,0.0008027878,0.01017599,0.001100792],"study_design_scores_gemma":[0.001050896,0.0001833649,0.02776073,0.00001325242,0.000007294568,0.00002308963,0.0003525695,0.00002353241,0.9164032,0.0002078375,0.05365659,0.0003176392],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9717602,0.0006741518,0.0005337116,0.0005267264,0.0000797231,0.00008989259,0.000002632377,0.00001404353,0.02631889],"genre_scores_gemma":[0.9730167,0.0005990925,0.006648043,0.0006604727,0.00009474152,0.00001796255,0.000326107,0.0000204476,0.01861647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06944772,"threshold_uncertainty_score":0.5382887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007953282641921014,"score_gpt":0.2364089222889046,"score_spread":0.2284556396469835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}